Department of Cardiovascular, The People's Hospital of Xuancheng City, Xuancheng City, Anhui Province, China; Department of Pacing Electrophysiology, Xinjiang Key Laboratory of Electrophysiology and Cardiac Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi City, Xinjiang Uygur Autonomous Region, China.
Department of Research and Teaching, The People's Hospital of Xuancheng City, Xuancheng City, Anhui Province, China.
Clinics (Sao Paulo). 2024 Aug 2;79:100448. doi: 10.1016/j.clinsp.2024.100448. eCollection 2024.
To study the complications and effectiveness of the treatment of chronic arrhythmias with cardiac Ganglion Plexus (GP) ablation, and to explore the value of the treatment of chronic arrhythmias with GP ablation.
This study was a one-arm interventional study of patients from the first hospital of Xinjiang Medical University and the People's Hospital of Xuancheng City admitted (09/2018-08/2021) because of bradyarrhythmia. The left atrium was modeled using the Carto3 mapping system. The ablation endpoint was the absence of a vagal response under anatomically localized and high-frequency stimulation guidance. Postoperative routine follow-up was conducted. Holter data at 3-, 6-, and 12-months were recorded.
Fifty patients (25 male, mean age 33.16 ± 7.89 years) were induced vagal response by either LSGP, LIGP, RAGP, or RIGP. The heart rate was stable at 76 bpm, SNRT 1.092s. DC, DR, HR, SDNN, RMSSD values were lower than that before ablation. AC, SSR, TH values were higher than those before ablation, mean heart rate and the slowest heart rate were significantly increased. There were significant differences in follow-up data between the preoperative and postoperative periods (all p < 0.05). All the patients were successfully ablated, and their blood pressure decreased significantly. No complications such as vascular damage, vascular embolism and pericardial effusion occurred.
Left Atrial GP ablation has good long-term clinical results and can be used as a treatment option for patients with bradyarrhythmia.
研究心脏神经节丛（GP）消融治疗慢性心律失常的并发症和疗效，探讨 GP 消融治疗慢性心律失常的价值。
本研究为单臂介入研究，纳入新疆医科大学第一附属医院和宣城市人民医院（2018 年 9 月至 2021 年 8 月）因缓慢性心律失常住院的患者。采用 Carto3 系统构建左心房模型。消融终点为在解剖定位和高频刺激引导下，无迷走神经反应。术后常规随访，记录术后 3、6、12 个月的动态心电图数据。
50 例患者（男 25 例，平均年龄 33.16±7.89 岁）分别通过 LSGP、LIGP、RAGP 或 RIGP 诱发迷走神经反应。心率稳定在 76 bpm，SNRT 为 1.092s。DC、DR、HR、SDNN、RMSSD 值均低于消融前，AC、SSR、TH 值均高于消融前，平均心率和最慢心率明显增加。术前和术后随访数据差异均有统计学意义（均 P<0.05）。所有患者均消融成功，血压明显下降，无血管损伤、血管栓塞、心包积液等并发症发生。
左心房 GP 消融治疗具有良好的长期临床效果，可作为缓慢性心律失常患者的治疗选择。
