The Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK; Institute for Life Sciences, University of Southampton, University Rd, Highfield, Southampton, SO17 1BJ, UK.
The Institute of Developmental Sciences, Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
Placenta. 2024 Sep 2;154:216-219. doi: 10.1016/j.placenta.2024.07.313. Epub 2024 Jul 31.
Placental structure is linked to function across morphological scales. In the placenta, changes to gross anatomy, such as surface area, volume, or blood vessel arrangement, are associated with suboptimal physiological outcomes. However, quantifying each of these metrics requires different laborious semi-quantitative methods. Here, we demonstrate how, with minimal sample preparation, whole-organ computed microtomography (microCT) can be used to calculate gross morphometry of the equine placenta and a range of additional metrics, including branching morphometry of placental vasculature, non-destructively from a single dataset. Our approach can be applied to quantify the gross structure of any large mammalian placenta.
胎盘结构与形态学尺度上的功能相关。在胎盘，大体解剖结构的变化，如表面积、体积或血管排列，与不理想的生理结果有关。然而，量化这些指标中的每一个都需要不同的繁琐的半定量方法。在这里，我们展示了如何在最小化样本制备的情况下，使用全器官计算微计算机断层扫描（microCT），从单个数据集非破坏性地计算马胎盘的大体形态和一系列其他指标，包括胎盘血管的分支形态。我们的方法可以应用于量化任何大型哺乳动物胎盘的大体结构。
