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基于双剂和加强针接种的 COVID-19 控制建模。

Modelling on COVID-19 control with double and booster-dose vaccination.

机构信息

Department of Mathematics, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara 144411, India.

Department of Mathematics, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara 144411, India.

出版信息

Gene. 2024 Nov 30;928:148795. doi: 10.1016/j.gene.2024.148795. Epub 2024 Aug 6.

Abstract

COVID-19 vaccines have been illustrated to lessen the growth of sickness caused by the virus effectively. In any case, inoculation has consistently been controversial, with differing opinions and viewpoints. This has compelled some individuals to decide against receiving the vaccine. These divergent viewpoints have had a trivial impact on the epidemic's dynamics and the disease's development. In response to vaccinated individuals still falling ill, many countries have implemented booster vaccines to protect further. In this specific investigation, a mathematical model composed of seven compartments is employed to examine the effectiveness of a booster dose in preventing and treating the transmission of COVID-19. The principles of mathematics are employed to analyse and investigate the dynamics of the disease. Using a qualitative prototype analysis, we acquired valuable insights into its effectiveness. One essential aspect is the basic reproduction number, a critical determinant of the disease's spread. This calculation is determined by studying the system's equilibrium and evaluating its stability. Furthermore, we examined the balance from a local and global viewpoint, considering the possibility of bifurcation and the model's reproductive number sensitivity index. Through numerical simulations, we have visually illustrated the analytical findings outlined in this research paper and presented a thorough examination of the efficacy of booster shots as a preventive and therapeutic measure in the spread dynamics of COVID-19.

摘要

COVID-19 疫苗已被证明能有效减轻病毒引起的疾病的传播。然而,接种疫苗一直存在争议,不同的观点和意见。这使得一些人决定不接种疫苗。这些不同的观点对疫情动态和疾病的发展产生了微不足道的影响。为应对接种疫苗的人仍会患病,许多国家已实施加强针疫苗以进一步进行保护。在本次具体研究中,采用了一个由七个部分组成的数学模型来检验加强剂量在预防和治疗 COVID-19 传播方面的有效性。数学原理被用于分析和研究疾病的动态。通过定性原型分析,我们获得了对其有效性的宝贵见解。一个重要方面是基本繁殖数,它是疾病传播的关键决定因素。这一计算是通过研究系统的平衡并评估其稳定性来确定的。此外,我们从局部和全局角度考虑了分岔的可能性以及模型的繁殖数敏感性指数,研究了这种平衡。通过数值模拟,我们直观地展示了本研究论文中分析结果,并全面检验了加强针作为 COVID-19 传播动态的预防和治疗措施的效果。

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