Zhou Jiawei, Wu Tao, Liu Wenhui
940th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China, Lanzhou, Gansu 730050, China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2024 Aug 10;41(8):1010-1015. doi: 10.3760/cma.j.cn511374-20210913-00746.
DNA methylation is an important epigenetic regulatory mechanism which plays a crucial role in cell differentiation and development. Its function is closely related to DNA methyltransferase 3 alpha (DNMT3A), which can affect gene expression and stem cell differentiation. The mutation rate of the DNMT3A gene is relatively high in Acute myeloid leukemia (AML), but its type and pathogenic mechanism are not yet clear. Further research on DNMT3A may help to identify its pathogenic targets and provide a basis for precise treatment of AML. This article has provided a review for the research progress on the expression of the DNMT3A gene in AML.
DNA甲基化是一种重要的表观遗传调控机制，在细胞分化和发育中起着关键作用。其功能与DNA甲基转移酶3α（DNMT3A）密切相关，DNMT3A可影响基因表达和干细胞分化。急性髓系白血病（AML）中DNMT3A基因的突变率相对较高，但其类型和致病机制尚不清楚。对DNMT3A的进一步研究可能有助于确定其致病靶点，并为AML的精准治疗提供依据。本文对AML中DNMT3A基因表达的研究进展进行了综述。
