Fleming S, Peppard S, Ratanatharathorn V, Schumacher M, Weaver A, Al-Sarraf M, Peters G
Am J Clin Oncol. 1985 Aug;8(4):302-6. doi: 10.1097/00000421-198508000-00005.
Forty-four patients were evaluated for ototoxicity following treatment with the chemotherapeutic agent cis-platinum. Statistically significant hearing changes at 2,000 Hz (p less than 0.001); 4,000 Hz (p less than 0.05); and 8,000 Hz (p less than 0.001) were observed. Chi-square analysis demonstrated that at 8,000 Hz patients who had lower than average thresholds prior to chemotherapy were more likely to experience greater threshold shift than those patients whose pre-chemotherapy thresholds were higher than average. In this patient sample, there was no significant correlation shown between serum creatinine levels and ototoxicity.
对44例接受化疗药物顺铂治疗后的患者进行了耳毒性评估。观察到在2000Hz（p<0.001）、4000Hz（p<0.05）和8000Hz（p<0.001）处有统计学显著的听力变化。卡方分析表明，在8000Hz处，化疗前阈值低于平均水平的患者比化疗前阈值高于平均水平的患者更有可能经历更大的阈值变化。在这个患者样本中，血清肌酐水平与耳毒性之间未显示出显著相关性。
