Murakami Keiko, Ishihara Junko, Takachi Ribeka, Sugawara Shiori, Aizawa Misato, Takahashi Ippei, Obara Taku, Ishikuro Mami, Noda Aoi, Ogino Mako, Hoshina Yuchie, Kito Kumiko, Nakadate Misako, Maruya Sachiko, Matsuno Tomoka, Yonezawa Yudai, Yamashita Takahiro, Suzuki Shigenori, Yamamoto Masayuki, Kuriyama Shinichi
Tohoku Medical Megabank Organization, Tohoku University.
Graduate School of Environmental Health, Azabu University.
J Epidemiol. 2025 Mar 5;35(3):109-117. doi: 10.2188/jea.JE20240064. Epub 2024 Nov 30.
The Tohoku Medical Megabank Project (TMM) was established to realize personalized healthcare and medicine using genomic and omics data. This study evaluated the validity and reproducibility of food group intakes derived from a self-administered food frequency questionnaire (TMM-FFQ) that included the response option "constitutionally unable to eat/drink it" among community-dwelling Japanese adults.
Participants comprised 89 men and 124 women aged ≥20 years from Miyagi Prefecture. Participants completed weighed food records (WFRs) for 3 consecutive days per season as reference intake and FFQs in 2019 (FFQ1) and 2021 (FFQ3). Spearman's rank correlation coefficients (CCs) were calculated for correlations between food group intakes estimated from the 12-day WFR and FFQ3 (validity), and for correlations between those estimated from the FFQ1 and FFQ3 (reproducibility). Cross-classification according to quintiles using FFQ and WFR data was also performed.
The percentage of participants who chose the "constitutionally unable to eat/drink it" option was non-negligible for some food groups. In the validity analysis, CCs were >0.40 for many food groups; the median across 21 food groups was 0.49 in men and 0.45 in women. The median percentages of cross-classification into exact plus adjacent quintiles were 73.0% in men and 66.9% in women. In the reproducibility analysis, CCs were >0.50 for many food groups; the median across 21 food groups was 0.60 in men and 0.51 in women.
The validity of the TMM-FFQ compared with 12-day WFR and the reproducibility of the TMM-FFQ were reasonable for food groups in the TMM cohort studies.
东北医学大数据项目（TMM）旨在利用基因组和组学数据实现个性化医疗保健和医学。本研究评估了社区居住的日本成年人中，一份自填式食物频率问卷（TMM-FFQ）得出的食物组摄入量的有效性和可重复性，该问卷包含“体质上无法食用/饮用”这一回答选项。
参与者包括来自宫城县的89名男性和124名年龄≥20岁的女性。参与者在每个季节连续3天完成称重食物记录（WFR）作为参考摄入量，并在2019年（FFQ1）和2021年（FFQ3）完成食物频率问卷。计算了根据12天WFR估计的食物组摄入量与FFQ3之间的相关性（有效性），以及根据FFQ1和FFQ3估计的食物组摄入量之间的相关性（可重复性）的斯皮尔曼等级相关系数（CCs）。还使用FFQ和WFR数据按五分位数进行了交叉分类。
对于某些食物组，选择“体质上无法食用/饮用”选项的参与者比例不可忽视。在有效性分析中，许多食物组的CCs>0.40；21个食物组的中位数在男性中为0.49，在女性中为0.45。交叉分类到精确加相邻五分位数的中位数百分比在男性中为73.0%，在女性中为66.9%。在可重复性分析中，许多食物组的CCs>0.50；21个食物组的中位数在男性中为0.60，在女性中为0.51。
在TMM队列研究中，与12天WFR相比，TMM-FFQ的有效性以及TMM-FFQ的可重复性对于食物组而言是合理的。
