Tokyo Women's Medical University, Department of Respiratory Medicine, 8-1, Kawadacho, Shinjuku, Tokyo, 1628666, Japan.
Tokyo Women's Medical University, Department of Infectious Diseases, 8-1, Kawadacho, Shinjuku, Tokyo, 1628666, Japan.
Respir Investig. 2024 Sep;62(5):884-888. doi: 10.1016/j.resinv.2024.07.016. Epub 2024 Aug 3.
Co-detection of respiratory pathogens with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is poorly understood. This descriptive epidemiological study aimed to determine the effect of the interaction of different respiratory pathogens on clinical variables.
We retrospectively reviewed the results of comprehensive multiplex polymerase chain reaction (PCR) testing from November 2020 to March 2023 to estimate respiratory pathogen co-detection rates in Shinjuku, Tokyo. We evaluated the interactions of respiratory pathogens, particularly SARS-CoV-2, between observed and expected co-detection. We estimated the trend of co-detection with SARS-CoV-2 in terms of age and sex and applied a multiple logistic regression model adjusted for age, testing period, and sex to identify influencing factors between co-detection and single detection for each pathogen.
Among 57,746 patients who underwent multiplex PCR testing, 10,516 (18.2%) had positive for at least one of the 22 pathogens. Additionally, 881 (1.5%) patients were confirmed to have a co-detection. SARS-CoV-2 exhibited negative interactions with adenovirus, coronavirus, human metapneumovirus, parainfluenza virus, respiratory syncytial virus, and rhino/enterovirus. SARS-CoV-2 co-detection with other pathogens occurred most frequently in patients of the youngest age group (0-4 years). A multiple logistic regression model indicated that younger age was the most influential factor for SARS-CoV-2 co-detection with other respiratory pathogens.
The study highlights the prevalence of SARS-CoV-2 co-detection with other respiratory pathogens in younger age groups, necessitating further exploration of the clinical implications and severity of SARS-CoV-2 co-detection.
严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 与呼吸道病原体的共同检测了解甚少。本描述性流行病学研究旨在确定不同呼吸道病原体相互作用对临床变量的影响。
我们回顾性分析了 2020 年 11 月至 2023 年 3 月在东京新宿进行的综合多重聚合酶链反应 (PCR) 检测结果，以估计呼吸道病原体的共同检出率。我们评估了呼吸道病原体，特别是 SARS-CoV-2 的相互作用，观察到的和预期的共同检出率。我们根据年龄和性别估计了与 SARS-CoV-2 的共同检出趋势，并应用多因素逻辑回归模型调整年龄、检测期和性别，以确定每个病原体共同检出和单独检出的影响因素。
在 57746 例行多重 PCR 检测的患者中，至少有一种 22 种病原体阳性的患者有 10516 例（18.2%）。此外，有 881 例（1.5%）患者被确诊为共同检出。SARS-CoV-2 与腺病毒、冠状病毒、人偏肺病毒、副流感病毒、呼吸道合胞病毒和鼻病毒/肠道病毒呈负相互作用。SARS-CoV-2 与其他病原体的共同检出最常发生在年龄最小的患者（0-4 岁）中。多因素逻辑回归模型表明，年龄较小是 SARS-CoV-2 与其他呼吸道病原体共同检出的最主要影响因素。
本研究强调了 SARS-CoV-2 在年龄较小的患者中与其他呼吸道病原体共同检出的流行情况，需要进一步探索 SARS-CoV-2 共同检出的临床意义和严重程度。
