Respiratory Department, Bordeaux University Hospital, 33604 Pessac, France.
Biodimed Conseils, 75009 Paris, France.
Infect Dis Now. 2024 Sep;54(6):104961. doi: 10.1016/j.idnow.2024.104961. Epub 2024 Aug 2.
In France, the goal of the pertussis vaccination program is to protect newborns. All infants are vaccinated under the program and then given booster shots up to the age of 25 years. Pregnant women are likewise vaccinated, with the cocooning strategy reserved for infants born to unvaccinated mothers. Real-world data shows (i) inadequate coverage among adolescents and adults under 25; (ii) improper use of the tetanus, diphtheria, and polio (Td/IPV) vaccine in children under six years, adolescents, and young adults; and (iii) underdiagnosis of pertussis in adults. Older patients or those with specific chronic medical conditions are at risk of developing severe disease. Improving the diagnosis and surveillance of pertussis in adults and seniors would be one of the first steps in the right direction. Aligning pertussis vaccination in adults with the Td/IPV program (boosters at 45, 65 years of age, and then every 10 years) would make the vaccination schedule simpler, easier to understand, and easier to implement. Large-scale awareness campaigns targeting this population would increase coverage, thereby boosting the effectiveness of the other measures.
在法国，百日咳疫苗接种计划的目标是保护新生儿。所有婴儿都按照该计划接种疫苗，然后在 25 岁之前进行加强针接种。孕妇也同样接种疫苗，对于未接种疫苗的母亲所生的婴儿则采用“围堵策略”。现实世界的数据表明：（i）12 岁以下青少年和 25 岁以下成年人的疫苗接种率不足；（ii）6 岁以下儿童、青少年和年轻成年人中破伤风、白喉和脊髓灰质炎（Td/IPV）疫苗的使用不当；（iii）成年人百日咳的诊断不足。老年患者或患有特定慢性疾病的患者有患重病的风险。改善成年人和老年人百日咳的诊断和监测将是朝着正确方向迈出的第一步。将成年人的百日咳疫苗接种与 Td/IPV 计划（45 岁、65 岁时加强针，然后每 10 年加强一次）相协调，将使接种计划更加简单、易于理解和实施。针对这一人群的大规模宣传活动将提高疫苗接种率，从而提高其他措施的效果。
