Khatri Abhishek, Prakash Om, Agarwal Rachna, Kushwaha Suman
Department of Psychiatry, Institute of Human Behaviour and Allied Sciences (IHBAS), New Delhi, India.
Department of Neurochemistry, Institute of Human Behaviour and Allied Sciences (IHBAS), New Delhi, India.
Indian J Psychiatry. 2024 Mar;66(3):287-292. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_975_23. Epub 2024 Mar 18.
To investigate the possible role of systemic inflammatory markers (interleukin; IL-6, C-reactive protein; CRP, and albumin levels) in the development of Alzheimer's dementia (AD) and also find their association with the severity of disease.
It was a cross-sectional study. Patients with Alzheimer's dementia (AD) and vascular dementia (VaD) from outpatient settings in tertiary care hospitals and non-demented controls (NDC) were recruited from the community. Individuals aged 50 years and older ( = 110) were included. Serum levels of IL-6, CRP, and albumin levels in patients with AD, VaD, and NDC were measured. The clinical Dementia Rating Scale was used for staging the severity of dementia. Serum levels of IL-6, CRP, and serum albumin were compared in study subjects and also analyzed with the severity of dementia in dementia subgroups.
Our main finding was that serum levels of IL-6 were significantly elevated in patients with AD and VaD (7.79 and 6.60) as compared to NDC (2.98) ( < 0.001). No significant difference in CRP or albumin levels was observed between the three groups. Serum IL-6 and CRP showed a positive correlation with the severity of AD, though the correlation was significant only for IL-6 (r = 0.777). The serum albumin levels showed a statistically significant negative correlation with the severity of AD (r > 0.3 but <0.5).
The study demonstrates a notable association between systemic inflammatory markers, particularly IL-6, and the severity of AD, indicating their potential role in its pathogenesis. These findings suggest that targeting these markers could offer new insights into therapeutic strategies for AD.
探讨全身炎症标志物（白细胞介素；IL-6、C反应蛋白；CRP和白蛋白水平）在阿尔茨海默病（AD）发生发展中的可能作用，并找出它们与疾病严重程度的关联。
这是一项横断面研究。从三级护理医院门诊的阿尔茨海默病（AD）和血管性痴呆（VaD）患者以及社区招募的非痴呆对照（NDC）中选取年龄在50岁及以上（n = 110）的个体。测量AD、VaD和NDC患者的血清IL-6、CRP和白蛋白水平。使用临床痴呆评定量表对痴呆严重程度进行分期。比较研究对象的血清IL-6、CRP和血清白蛋白水平，并在痴呆亚组中分析它们与痴呆严重程度的关系。
我们的主要发现是，与NDC（2.98）相比，AD和VaD患者的血清IL-6水平显著升高（分别为7.79和6.60）（P < 0.001）。三组之间CRP或白蛋白水平未观察到显著差异。血清IL-6和CRP与AD严重程度呈正相关，尽管仅IL-6的相关性显著（r = 0.777）。血清白蛋白水平与AD严重程度呈统计学显著负相关（r > 0.3但<0.5）。
该研究表明全身炎症标志物，特别是IL-6，与AD严重程度之间存在显著关联，表明它们在其发病机制中的潜在作用。这些发现表明，针对这些标志物可能为AD的治疗策略提供新的见解。
