Wani Parvaze Ahmad, Omobolanle Lawal Aolat, Hamid Burhan, Fayokemi Raheem Aishat, Perveen Kahkashan, Bukhari Najat A, Sayyed R Z, Mastinu Andrea
Department of Biological Sciences, College of Natural and Applied Sciences, Crescent University, Abeokuta, 111105, Nigeria.
Centre of Research for Development, University of Kashmir, Srinagar, 190006, India.
Heliyon. 2024 Jul 6;10(14):e34128. doi: 10.1016/j.heliyon.2024.e34128. eCollection 2024 Jul 30.
Recently, there has been an increasing demand for medicinal plants to control diseases for good health and well-being, as primary health facilities are inadequate in certain populations to cure infections. Since synthetic medicines are toxic to humans and other animals, the present research is thus focused on using traditional medicine for treating various ailments as they are harmless. Based on the above facts, the current study was conducted to assay the antimicrobial, anti-diabetic, anti-cholinesterase, anti-oxidant, anti-quorum sensing, and anti-antibiotic resistance modifying effect of extracts of . This study found 37 and 30 chemicals in butanol and dichloromethane (DCM) extracts using a gas chromatograph mass spectrophotometer (GC-MS). Most active compounds identified were benzofuran, 2,3-dihydro-, 1,2,3-benzenetriol, 3-bornanone, oxime and oleic acid by extracts of butanol whereas dichloromethane extracted three major active compounds (2,3-dihydro-3,5-dihydroxy-, 4H-pyran-4-one 3-deoxy-d-mannoic lactone and 5-hydroxymethylfurfural). Both dichloromethane and butanol extracts showed the highest antimicrobial activity. Compared to aqueous extracts, dichloromethane, and butanol showed excellent anti-diabetic anti-cholinesterase activities and inhibited virulence factors regulated by quorum sensing (QS). Anti-oxidants increased in solvent extracts (DCM and butanol) compared to aqueous extracts. Results of scanning electron microscope (SEM) and Fourier Transmission Infrared (FTIR) indicated damage to the cell membrane of by the formation of pits and breakage in functional groups exposed to the extracts of butanol and dichloromethane compared to aqueous extracts. The above results confirmed that can be an alternative medicine for treating diseases.
最近，由于某些人群的初级卫生设施不足以治愈感染，对药用植物以控制疾病促进健康和福祉的需求日益增加。由于合成药物对人类和其他动物有毒，因此目前的研究集中在使用传统药物治疗各种疾病，因为它们是无害的。基于上述事实，进行了本研究以测定[植物名称]提取物的抗菌、抗糖尿病、抗胆碱酯酶、抗氧化、抗群体感应和抗抗生素抗性修饰作用。本研究使用气相色谱 - 质谱仪（GC-MS）在丁醇和二氯甲烷（DCM）提取物中发现了37种和30种化学物质。丁醇提取物鉴定出的最具活性的化合物是苯并呋喃、2,3 - 二氢 - 、1,2,3 - 苯三醇、3 - 冰片酮、肟和油酸，而二氯甲烷提取出三种主要活性化合物（2,3 - 二氢 - 3,5 - 二羟基 - 、4H - 吡喃 - 4 - 酮3 - 脱氧 - D - 甘露糖内酯和5 - 羟甲基糠醛）。二氯甲烷和丁醇提取物均表现出最高的抗菌活性。与水提取物相比，二氯甲烷和丁醇表现出优异的抗糖尿病、抗胆碱酯酶活性，并抑制群体感应（QS）调节的毒力因子。与水提取物相比，溶剂提取物（DCM和丁醇）中的抗氧化剂增加。扫描电子显微镜（SEM）和傅里叶变换红外光谱（FTIR）的结果表明，与水提取物相比，暴露于丁醇和二氯甲烷提取物的[细菌名称]细胞膜因形成凹坑和官能团断裂而受损。上述结果证实[植物名称]可以作为治疗疾病的替代药物。
