Haghjoo Majid, Askarinejad Amir, Heidarali Mona, Bakhshandeh Hooman, Fazelifar Amirfarjam, Emkanjoo Zahra, Madadi Shabnam, Kamali Farzad, Noohi Fereidoun
Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Department of Cardiac Electrophysiology, Rajaie Cardiovascular Medical and Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Int J Cardiol Heart Vasc. 2024 Jul 8;53:101461. doi: 10.1016/j.ijcha.2024.101461. eCollection 2024 Aug.
The Atrial Fibrillation Better Care (ABC) pathway is such an integrated care approach, recommended in guidelines. The aim of this service evaluation study was to evaluate the impact of implementing the ABC pathway in Iranian population.
In this prospective longitudinal cohort study, consecutive patients with a diagnosis of AF were initially evaluated. Patients at baseline were evaluated in hence of adherence to ABC pathway strategy. After study enrolment, first and second follow-up service evaluations were conducted at 6 and 12 months, respectively.
The use of vitamin K antagonists (VKA) decreased from 25.1 % at enrolment to 13.8 % at follow-up; instead, non-VKA oral anticoagulants (NOAC) utilization increased from 40.0 % to 86.1 %, while antiplatelet treatment decreased from 34.9 % to 0 %. Use of antihypertensive drugs, ARBs, diuretics, and statins increased after implementation of the ABC pathway. Implementation of the ABC pathway approach led to a decrease in the occurrence of stroke/TIA (from 6.3 % to 2.2 %, p = 0.002), systemic thromboembolism (from 1.4 % to 0.0 %, p = 0.04), nose bleeds (from 0.8 % to 0.6 %, p = 0.04), skin bruising (from 1.2 % to 0.0 %, p = 0.002), and heart failure (from 7.7 % to 4.7 %, p = 0.04). The proportion of patients in EHRA Class I-II increased from 93.3 % at enrolment to 98.1 % at follow-up.
In this first study from a Middle East population, compliance with ABC pathway strategy in the management of AF was associated with optimization of management and general improvements in patient outcomes during follow-up.
心房颤动优化治疗(ABC)路径是指南中推荐的一种综合治疗方法。本服务评估研究的目的是评估在伊朗人群中实施ABC路径的影响。
在这项前瞻性纵向队列研究中,对连续诊断为房颤的患者进行了初步评估。对基线时的患者进行ABC路径策略依从性评估。研究入组后,分别在6个月和12个月进行了首次和第二次随访服务评估。
维生素K拮抗剂(VKA)的使用从入组时的25.1%降至随访时的13.8%;相反,非VKA口服抗凝剂(NOAC)的使用从40.0%增加到86.1%,而抗血小板治疗从34.9%降至0%。ABC路径实施后,抗高血压药物、ARB、利尿剂和他汀类药物的使用增加。ABC路径方法的实施导致中风/短暂性脑缺血发作(TIA)的发生率降低(从6.3%降至2.2%,p = 0.002)、系统性血栓栓塞(从1.4%降至0.0%,p = 0.04)、鼻出血(从0.8%降至0.6%,p = 0.04)、皮肤瘀伤(从1.2%降至至0.0%,p = 0.00)和心力衰竭(从7.7%降至4.7%,p = 0.04)。欧洲心律协会(EHRA)I-II级患者的比例从入组时的93.3%增加到随访时的98.1%。
在这项来自中东人群的首次研究中,房颤管理中对ABC路径策略的依从性与管理优化及随访期间患者结局的总体改善相关。