Ruan Jinping, Fu Zhou, Ying Linyan
Department of Pediatrics, Chongqing Red Cross Hospital (People's Hospital of Jiangbei District), Chongqing, China.
Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Front Pediatr. 2024 Jul 19;12:1409687. doi: 10.3389/fped.2024.1409687. eCollection 2024.
pneumonia (MPP) and pneumonia (SPP) are frequent causes of respiratory tract infection, the aims of the study were to explore the differences in clinical features between children with MPP and those with SPP.
This retrospective study included admitted children who were diagnosed with MPP or SPP over 5 years from January 2015 to January 2020. Children with MPP were compared to children with SPP in terms of clinical features.
506 patients with MPP were compared to 311 patients with SPP in terms of clinical differences. The MPP group with a median age of 60 [29-89] months and the SPP group with a median age of 24 [10-40] months. Patients with MPP were older and had a higher occurrence of receiving antibiotics before admission, fever, dry cough, polypnea and diarrhea than patients with SPP (all < 0.01). Patients with SPP were more likely to have wheezing, cyanosis and irritability (all < 0.01). Laboratory findings in our study showed that there were significant differences between MPP and SPP patients in mean leucocyte count, neutrophil % (N%), lymphocyte % (L%), ALT levels, AST levels, LDH levels and incidence of accelerated procalcitonin (PCT) (all < 0.01). Lower age, no dry cough, no polypnea, lower LDH levels, and higher PCT might lead to the diagnosis of SPP. Our study showed that age had a higher accuracy in predicting MPP than LDH levels, with an age >48.5 months shown to be an independent predictive factor for the early evaluation and identification of MPP.
In conclusion, patients with MPP and SPP usually present with fever, cough and some nonspecific symptoms. Our study showed that age, dry cough, polypnea, LDH levels, and PCT levels were independent predictive factors associated with MPP and SPP.
支原体肺炎（MPP）和细菌性肺炎（SPP）是呼吸道感染的常见病因，本研究旨在探讨MPP患儿与SPP患儿临床特征的差异。
本回顾性研究纳入了2015年1月至2020年1月这5年间收治的诊断为MPP或SPP的患儿。比较MPP患儿与SPP患儿的临床特征。
比较了506例MPP患儿与311例SPP患儿的临床差异。MPP组中位年龄为60[29 - 89]个月，SPP组中位年龄为24[10 - 40]个月。MPP患儿比SPP患儿年龄更大，入院前接受抗生素治疗、发热、干咳、气促和腹泻的发生率更高（均P<0.01）。SPP患儿更易出现喘息、发绀和烦躁（均P<0.01）。本研究的实验室检查结果显示，MPP和SPP患儿在平均白细胞计数、中性粒细胞百分比（N%）、淋巴细胞百分比（L%）、谷丙转氨酶水平、谷草转氨酶水平、乳酸脱氢酶水平及降钙素原（PCT）升高发生率方面存在显著差异（均P<0.01）。年龄较小、无干咳、无气促、乳酸脱氢酶水平较低及降钙素原较高可能提示为SPP。本研究表明，年龄在预测MPP方面比乳酸脱氢酶水平具有更高的准确性，年龄>48.5个月是早期评估和识别MPP的独立预测因素。
总之，MPP和SPP患者通常表现为发热、咳嗽及一些非特异性症状。本研究表明，年龄、干咳、气促、乳酸脱氢酶水平及降钙素原水平是与MPP和SPP相关的独立预测因素。
