Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
Transpl Int. 2024 Jul 19;37:12708. doi: 10.3389/ti.2024.12708. eCollection 2024.
Liver transplantation is the only curative option for many liver diseases that end up in liver failure, and cholangiopathy remains a challenging complication post-liver transplant, associated with significant morbidity and potential graft loss. The low availability of organs and high demand for transplantation motivate scientists to find novel interventions. Organoids, as three-dimensional cell cultures derived from adult cells or induced pluripotent cells, may help to address this problem. Different types of organoids have been described, from which cholangiocyte organoids offer a high level of versatility and plasticity for a deeper study of liver disease mechanisms. Cholangiocytes can be obtained from different segments of the biliary tree and have shown a remarkable capacity to adapt to new environments, presenting an effective system for studying cholangiopathies. Studies using cholangiocyte organoids show promising results for disease modeling, where organoids offer fundamental features to recapitulate the complexities of tissues and uncover fundamental pathological pathways to potentially reveal therapeutic strategies for personalized medicine. Organoids could hold the potential for regeneration of injured livers, representing tools of clinical impact in regenerative medicine when tissue damage is already present.
肝移植是许多终末期肝病导致肝功能衰竭的唯一治愈选择，胆管病仍然是肝移植后的一个具有挑战性的并发症，与显著的发病率和潜在的移植物丢失有关。器官的供应不足和对移植的高需求促使科学家寻找新的干预措施。类器官是从成体细胞或诱导多能细胞衍生的三维细胞培养物，可能有助于解决这个问题。已经描述了不同类型的类器官，其中胆管细胞类器官为深入研究肝脏疾病机制提供了高度的多功能性和可塑性。胆管细胞可以从胆管树的不同节段获得，并且已经显示出对新环境的显著适应能力，为研究胆管病提供了有效的系统。使用胆管细胞类器官的研究为疾病建模提供了有希望的结果，其中类器官提供了基本特征来重现组织的复杂性，并揭示潜在的治疗策略，以实现个性化医疗。类器官有可能使受损肝脏再生，当组织损伤已经存在时，代表着再生医学中具有临床影响的工具。
