Krishnan Venkatram, Ram Adhitya, Rana Abhilasha, Jaganathan Sriram, Jayappa Sateesh, Glasier Charles, Vattoth Surjith, Ramakrishnaiah Raghu
University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Little Rock Central High School, Little Rock, AR, USA.
Ultrasound. 2024 Aug;32(3):172-177. doi: 10.1177/1742271X231225121. Epub 2024 Feb 14.
The thymus normally forms in the neck from the third pharyngeal pouch and descends to its normal position in the mediastinum. Arrest of descent or sequestration of thymic tissue can occur at any point along its path leading to an ectopic thymus which can present as a neck mass, usually in the paediatric age group.
Ultrasound is generally performed in the presence of a neck mass in children. Although a characteristic 'starry sky' appearance of the thymus has been described on ultrasound, it is not considered sufficiently specific and cross-sectional imaging with magnetic resonance imaging is usually performed. On magnetic resonance imaging, the ectopic thymus appears as a homogeneous T1 isointense and T2 hyperintense mass and may actually appear ominous due to the tendency of ectopic thymus to sometimes show diffusion restriction unlike the normal thymus. Subsequent invasive biopsy or surgical removal is usually necessary to rule out a neoplastic lesion. In our observation, the ultrasound appearance of thymus is sufficiently distinctive to be confidently diagnosed as ectopic thymic tissue. This appearance is similar to the high-resolution appearance of an embroidery yarn. The reason most radiologists are not aware of the same is because the normal mediastinal thymus is not usually imaged by ultrasound.
An accurate diagnosis on ultrasound would mean avoidance of expensive cross-sectional imaging and invasive biopsy or surgical excision in favour of regular non-invasive follow-up ultrasound scans until the lesion involutes in late childhood.
胸腺通常在颈部由第三咽囊形成,并下降至纵隔的正常位置。胸腺组织在其下降路径上的任何一点都可能发生下降停滞或隔离,导致异位胸腺,通常在儿童年龄组中表现为颈部肿块。
儿童出现颈部肿块时通常会进行超声检查。尽管超声检查中已描述胸腺具有特征性的“星空”外观,但它被认为特异性不足,通常会进行磁共振成像的横断面成像。在磁共振成像上,异位胸腺表现为均匀的T1等信号和T2高信号肿块,由于异位胸腺有时会出现与正常胸腺不同的扩散受限,实际上可能看起来很可疑。通常需要随后进行侵入性活检或手术切除以排除肿瘤性病变。在我们的观察中,胸腺的超声表现具有足够的特异性,可以确诊为异位胸腺组织。这种表现类似于绣花线的高分辨率外观。大多数放射科医生不了解这一点的原因是因为正常的纵隔胸腺通常不通过超声成像。
超声准确诊断意味着避免进行昂贵的横断面成像以及侵入性活检或手术切除,而是进行定期的非侵入性超声随访扫描,直到病变在儿童后期消退。