Hanna N F, Taylor-Robinson D, Kalodiki-Karamanoli M, Harris J R, McFadyen I R
Br J Obstet Gynaecol. 1985 Dec;92(12):1267-71. doi: 10.1111/j.1471-0528.1985.tb04874.x.
The vaginal pH, microbial flora and presence of clue cells were investigated in 89 women who were seen at a sexually transmitted diseases clinic with a vaginal discharge or because they were contacts of men with gonococcal or non-gonococcal urethritis or because they were seeking a routine examination. None of the women had received antibiotics for at least 4 weeks before examination. A clinically normal vaginal secretion was found in 21 (55%) of 38 women who had a vaginal pH of 5.0-5.5, while such a secretion was found in only 7 (14%) of 51 women who had a pH value of 6.0-7.5. Clue cells, Chlamydia trachomatis and Mycoplasma hominis were found two to three times more often in women with the higher pH value than in those with the lower value and Ureaplasma urealyticum and Trichomonas vaginalis also occurred more frequently in the former group. Furthermore, large numbers of M. hominis organisms (greater than or equal to 10(6) colour changing units/ml) were associated significantly with the higher pH value. However, there was no appreciable difference in the distribution of Candida albicans between the two groups. C. trachomatis but not the other micro-organisms was isolated most often from women who were taking oral contraceptives. The results indicate that a pH of greater than or equal to 6.0 is strongly predictive of infection and may be more useful than the type of discharge in suggesting a need for confirmatory microbiological tests.
对89名女性进行了阴道pH值、微生物菌群及线索细胞检查。这些女性因阴道分泌物异常、或为淋菌性或非淋菌性尿道炎男性患者的性接触者、或因寻求常规检查而就诊于性传播疾病门诊。所有女性在检查前至少4周未使用过抗生素。阴道pH值为5.0 - 5.5的38名女性中，21名（55%）阴道分泌物临床正常；而pH值为6.0 - 7.5的51名女性中，只有7名（14%）阴道分泌物临床正常。pH值较高的女性中，线索细胞、沙眼衣原体和解脲脲原体的检出率是pH值较低女性的两到三倍，人型支原体和阴道毛滴虫在前一组中也更常见。此外，大量人型支原体（大于或等于10⁶ 颜色改变单位/毫升）与较高的pH值显著相关。然而，两组白色念珠菌的分布没有明显差异。沙眼衣原体而非其他微生物最常从服用口服避孕药的女性中分离出来。结果表明，pH值大于或等于6.0强烈预示感染，在提示是否需要进行微生物学确诊检查方面可能比分泌物类型更有用。
