Kulyadi Chitra Pai, Noojibail Anupama, Arun Kumar Nayanatara, Kollampare Sowndarya, Dass Prameela Manoor
Department of Radiology , University of Colorado, Anschutz Medical Campus , Aurora , Colorado, USA.
Department of Physiology , Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal , 576104, India.
J Adv Vet Anim Res. 2024 Jun 12;11(2):449-454. doi: 10.5455/javar.2024.k794. eCollection 2024 Jun.
Chronic stress arises from stressful situations in day-to-day life that are ignored or managed incorrectly. Long-term stress can have negative effects, especially when it plays a role in the development of neurological illnesses. Severe stress can also negatively impact emotional well-being. Virgin coconut oil (VCO) has numerous health advantages. The aim of this study was to assess how VCO affected the biochemical and behavioral characteristics of Wistar albino rats exposed to chronic, unpredictable stress.
Healthy Wistar albino rats (150-200 gm) were split into two groups: experimental group and control group. Based on stress exposure and treatment with VCO and antidepressants, they were further divided into various subgroups. A chronic, unpredictable stress procedure was given for 21 days. After the experimental procedure, the rats were anesthetized, and through a cardiac puncture, blood was collected. The liver and brain were dissected to estimate different biochemical markers.
VCO proved to be a protective agent against chronic, unpredictable stress-induced changes in the biochemical parameters, hepatic enzyme activity, lipid profile, oxidative stress, and cognition.
VCO might be helpful as an effective natural treatment that can be utilized to effectively combat chronic, unpredictable stress-induced changes in brain and liver tissue.
慢性应激源于日常生活中被忽视或处理不当的应激情况。长期应激会产生负面影响，尤其是在神经疾病的发展过程中起作用时。严重应激还会对情绪健康产生负面影响。初榨椰子油（VCO）具有众多健康益处。本研究的目的是评估VCO如何影响暴露于慢性、不可预测应激的Wistar白化大鼠的生化和行为特征。
将健康的Wistar白化大鼠（150 - 200克）分为两组：实验组和对照组。根据应激暴露以及VCO和抗抑郁药的治疗情况，它们被进一步分为不同的亚组。给予21天的慢性、不可预测应激程序。实验程序结束后，将大鼠麻醉，通过心脏穿刺采集血液。解剖肝脏和大脑以评估不同的生化标志物。
VCO被证明是一种针对慢性、不可预测应激诱导的生化参数、肝酶活性、血脂谱、氧化应激和认知变化的保护剂。
VCO作为一种有效的自然疗法可能会有所帮助，可用于有效对抗慢性、不可预测应激诱导的脑和肝组织变化。
