Kurinami Noboru, Ashida Kenji, Sugiyama Seigo, Morito Yoko, Yoshida Akira, Hieshima Kunio, Miyamoto Fumio, Kajiwara Keizo, Jinnouchi Katsunori, Jinnouchi Hideaki, Nomura Masatoshi
Kurinami Clinic, 76-1 Kanzakimachi, Edagari, Kanzaki, Saga 842-0006 Japan.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
Diabetol Int. 2024 May 28;15(3):562-568. doi: 10.1007/s13340-024-00732-7. eCollection 2024 Jul.
This study aimed to investigate the relationship between plasma glucose profiles and periodontal disease (PD) severity in men and women.
We conducted a cross-sectional cohort study, enrolling all eligible patients with type 2 diabetes mellitus (T2DM) who regularly visited the outpatient department.
Patients were divided into severe and non-severe PD groups. The severe PD group showed a male predominance and significantly higher hemoglobin A1c (HbA1c) levels than the non-severe PD group. The optimal HbA1c cutoff value on the receiver operating characteristic curve for predicting severe PD was 7.3% [56 mmol/mol] (sensitivity, 52%; specificity, 73%; = 0.01). Multivariate logistic regression revealed that male sex (odds ratio [OR], 2.75; 95% confidence interval [CI], 1.19-6.34; P = 0.01) and higher HbA1c levels (OR, 3.09; 95% CI, 1.42-6.70; < 0 .01) were independently and significantly associated with the presence of severe PD. The prevalence rates of severe PD in patients with HbA1c levels < 7.3% [56 mmol/mol] and HbA1c levels ≥ 7.3% [56 mmol/mol] were 17.4% and 53.3% in women, and 50.0% and 66.7% in men, respectively.
Men with T2DM had a high risk of severe PD independent of HbA1c levels. Plasma glucose management may be crucial for maintaining periodontal health in T2DM patients, particularly in women.
本研究旨在调查男性和女性的血糖谱与牙周疾病（PD）严重程度之间的关系。
我们进行了一项横断面队列研究，纳入了所有定期到门诊就诊的符合条件的2型糖尿病（T2DM）患者。
患者被分为重度和非重度PD组。重度PD组男性居多，糖化血红蛋白（HbA1c）水平显著高于非重度PD组。预测重度PD的受试者工作特征曲线上的最佳HbA1c临界值为7.3%[56 mmol/mol]（灵敏度为52%；特异性为73%；P = 0.01）。多因素逻辑回归显示，男性（比值比[OR]为2.75；95%置信区间[CI]为1.19 - 6.34；P = 0.01）和较高的HbA1c水平（OR为3.09；95%CI为1.42 - 6.70；P < 0.01）与重度PD的存在独立且显著相关。HbA1c水平<7.3%[56 mmol/mol]和HbA1c水平≥7.3%[56 mmol/mol]的患者中，重度PD的患病率在女性中分别为17.4%和53.3%，在男性中分别为50.0%和66.7%。
患有T2DM的男性患重度PD风险高，与HbA1c水平无关。血糖管理对于维持T2DM患者的牙周健康可能至关重要，尤其是在女性中。
