铑（III）催化1-芳基吲唑酮与炔基环丁醇的[4 + 1]环化反应：通向吲唑并[1,2 - ]吲唑酮的方法
Rh(III)-catalyzed [4 + 1] annulation of 1-arylindazolones with alkynyl cyclobutanols: access to indazolo[1,2-]indazolones.
作者信息
Hu Jiang, Liu Jidan, Cui Wenwen, Zheng Liyao, Wang Renjie, Liu Zhao-Qing, Pu Shouzhi
机构信息
Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, 330013, P. R. China.
School of Chemistry and Chemical Engineering/Institute of Clean Energy and Materials/Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou, 510006, P. R. China.
出版信息
Org Biomol Chem. 2024 Aug 14;22(32):6500-6505. doi: 10.1039/d4ob01067a.
A convenient and efficient synthesis of structurally diverse indazolo[1,2-]indazolones a Rh(III)-catalyzed [4 + 1] annulation of 1-arylindazolones with alkynyl cyclobutanols has been achieved by combining C-H and C-C bond cleavage. This cascade reaction features readily available starting materials, good functional group tolerance, broad substrate scope, and excellent atom-economy.
通过结合C-H和C-C键裂解，实现了一种便捷高效的结构多样的吲唑并[1,2 - ]吲唑酮的合成方法，即铑(III)催化1-芳基吲唑酮与炔基环丁醇的[4 + 1]环化反应。该串联反应具有起始原料易得、官能团耐受性好、底物范围广和原子经济性优异等特点。
Zotero 插件