季碳中心吲哚并[1,2 -]喹唑啉酮和吲唑并[1,2 -]吲唑酮的合成：C-H官能化反应

Synthesis of quaternary carbon-centered indolo[1,2-]quinazolinones and indazolo[1,2-]indazolones C-H functionalization.

作者信息

Gogoi Kongkona, Bora Bidisha R, Borah Geetika, Sarma Bipul, Gogoi Sanjib

机构信息

Applied Organic Chemistry, Chemical Sciences & Technology Division, CSIR-North East Institute of Science and Technology, Jorhat-785006, AcSIR, Ghaziabad-201002, India.

Department of Chemistry, Dibrugarh University, Dibrugarh-786004, India.

出版信息

Chem Commun (Camb). 2021 Feb 11;57(11):1388-1391. doi: 10.1039/d0cc07419e.

DOI:10.1039/d0cc07419e

PMID:33438711

Abstract

An unprecedented Ru(ii)-catalyzed Csp2-H bond activation and annulation reaction of phenylindazolones with diaryl-substituted alkynes and dialkyl-substituted alkynes provided efficient routes for the construction of all-carbon quaternary-centered indolo[1,2-a]quinazolinones and quaternary carbon-centered indazolo[1,2-a]indazolones, respectively. The indolo[1,2-a]quinazolinones were fomed via Csp2-H activation, alkyne insertion and a 1,2-phenyl shift. Indazolo[1,2-a]indazolones were formed through a cascade reaction via the formation of exocyclic double bonds containing indolo[1,2-a]quinazolinones.

摘要

一种前所未有的钌（II）催化的苯并吲唑酮与二芳基取代炔烃和二烷基取代炔烃的Csp2-H键活化和环化反应，分别为构建全碳季碳中心的吲哚并[1,2-a]喹唑啉酮和季碳中心的吲唑并[1,2-a]吲唑酮提供了有效途径。吲哚并[1,2-a]喹唑啉酮通过Csp2-H活化、炔烃插入和1,2-苯基迁移形成。吲唑并[1,2-a]吲唑酮通过包含吲哚并[1,2-a]喹唑啉酮的环外双键形成的串联反应形成。