昆特精油的抗真菌活性可通过 N-乙酰半胱氨酸和伊曲康唑增强。
Anticandidal activity of Kunth essential oil is enhanced by N-acetylcysteine and itraconazole.
机构信息
Drug Research & Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil.
School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
出版信息
Future Microbiol. 2024;19(15):1309-1320. doi: 10.1080/17460913.2024.2380601. Epub 2024 Aug 5.
Evaluate the anticandidal effect of Kunth essential oil and its interaction with azoles and N-acetylcysteine (NAC) against planktonic cells and biofilms. Broth microdilution and checkerboard methods were used to evaluate the individual and combined activity with fluconazole and itraconazole (ITRA). The antibiofilm effect of the oil was assessed in 96-well plates alone and combined with ITRA and NAC, and cytotoxicity determined by MTT. The oil inhibited all species growth. The activity was enhanced when associated with ITRA and NAC for planktonic cells and biofilms in formation. The effective concentrations were lower than the toxic ones to V79 cells. Kunth essential oil is an anticandidal alternative, and can be associated with ITRA and NAC.
评估昆特精油对浮游细胞和生物膜的抗真菌作用及其与唑类药物和 N-乙酰半胱氨酸 (NAC) 的相互作用。采用肉汤微量稀释法和棋盘法评估与氟康唑和伊曲康唑 (ITRA) 的单独和联合活性。单独评估油以及与 ITRA 和 NAC 联合使用对生物膜的抗生物膜作用，并通过 MTT 测定细胞毒性。该油抑制了所有种属的生长。当与 ITRA 和 NAC 联合用于浮游细胞和形成的生物膜时，其活性增强。有效浓度低于对 V79 细胞的毒性浓度。昆特精油是一种抗真菌的替代物，可以与 ITRA 和 NAC 联合使用。
Zotero 插件