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二氢杨梅素通过靶向 S100A16 来防止去势雌鼠骨髓脂肪组织（MAT）扩张。

Icariside II protects from marrow adipose tissue (MAT) expansion in estrogen-deficient mice by targeting S100A16.

机构信息

Department of Orthopedics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China.

出版信息

J Mol Endocrinol. 2024 Sep 18;73(3). doi: 10.1530/JME-24-0020. Print 2024 Oct 1.

DOI:10.1530/JME-24-0020
PMID:39101576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11466200/
Abstract

Icariside II, a flavonoid glycoside, is the main component found invivo after the administration of Herba epimedii and has shown some pharmacological effects, such as prevention of osteoporosis and enhancement of immunity. Increased levels of marrow adipose tissue are associated with osteoporosis. S100 calcium-binding protein A16 (S100A16) promotes the differentiation of bone marrow mesenchymal stem cells (BMSCs) into adipocytes. This study aimed to confirm the anti-lipidogenesis effect of Icariside II in the bone marrow by inhibiting S100A16 expression. We used ovariectomy (OVX) and BMSC models. The results showed that Icariside II reduced bone marrow fat content and inhibited BMSCs adipogenic differentiation and S100A16 expression, which correlated with lipogenesis. Overexpression of S100A16 eliminated the inhibitory effect of Icariside II on lipid formation. β-catenin participated in the regulation adipogenesis mediated by Icariside II/S100A16 in the bone. In conclusion, Icariside II protects against OVX-induced bone marrow adipogenesis by downregulating S100A16, in which β-catenin might also be involved.

摘要

二苯乙烯苷是一种黄酮苷类化合物，是淫羊藿给药后体内发现的主要成分，具有一些药理作用，如预防骨质疏松症和增强免疫力。骨髓脂肪组织水平的增加与骨质疏松症有关。S100 钙结合蛋白 A16（S100A16）促进骨髓间充质干细胞（BMSCs）向脂肪细胞分化。本研究旨在通过抑制 S100A16 的表达，证实二苯乙烯苷在骨髓中的抗脂生成作用。我们使用卵巢切除（OVX）和 BMSC 模型。结果表明，二苯乙烯苷降低了骨髓脂肪含量，抑制了 BMSCs 的成脂分化和 S100A16 的表达，与脂生成相关。S100A16 的过表达消除了二苯乙烯苷对脂形成的抑制作用。β-连环蛋白参与了二苯乙烯苷/S100A16 在骨中调节的脂肪生成。总之，二苯乙烯苷通过下调 S100A16 来保护 OVX 诱导的骨髓脂肪生成，其中β-连环蛋白也可能参与其中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/60ea4bf91916/JME-24-0020fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/cebb4bf8cb8b/JME-24-0020fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/fb15e1fc3c0f/JME-24-0020fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/56e682d8fcf8/JME-24-0020fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/b56e6ab0a875/JME-24-0020fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/60ea4bf91916/JME-24-0020fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/cebb4bf8cb8b/JME-24-0020fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/fb15e1fc3c0f/JME-24-0020fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/56e682d8fcf8/JME-24-0020fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/b56e6ab0a875/JME-24-0020fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/11466200/60ea4bf91916/JME-24-0020fig5.jpg

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Biomed Chromatogr. 2023 Sep;37(9):e5686. doi: 10.1002/bmc.5686. Epub 2023 Jun 5.
4
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Expert Rev Gastroenterol Hepatol. 2023 Mar;17(3):263-272. doi: 10.1080/17474124.2023.2174968. Epub 2023 Feb 6.
5
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6
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7
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