Wu Xiaohong, Chen Yali, Luo Tuo, Liu Yusong, Zeng Lin
Department of Anesthesiology, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.
Department of Anesthesiology, Shifang People's Hospital, Shifang, Sichuan Province, China.
J Perianesth Nurs. 2025 Apr;40(2):281-287. doi: 10.1016/j.jopan.2024.04.006. Epub 2024 Aug 3.
Gastroscopy is one of the most commonly used diagnostic modalities for upper gastrointestinal disorders. Remazolam besylate, a new type of ultrashort-acting benzodiazepine drug, has been less studied in gastroscopy. In this study, we studied the efficacy and safety of remazolam combined with propofol for painless gastroscopy.
This was a single-center, placebo-controlled randomized trial.
One hundred patients undergoing painless gastroscopy were included in this study and randomly divided into 2 groups (n = 50 per group): the control group (Con group) and the remazolam group (Rem group). Sufentanil, remazolam, and propofol were used to anesthetize the patients, and then, the effects of different solutions on these patients were compared and analyzed. The patient's general condition, vital signs at different times, the dosage of propofol (mg) and additional times, complications, duration of gastroscopy (minutes), recovery time (minutes), length of stay in the recovery room (minutes), and adverse reactions were recorded.
Rem group systolic blood pressure was more stable (P < .05). The amount of additional propofol in Rem group was less (P < .05). The incidence of hypotension, bradycardia, and dizziness was lower in Rem group, as well as the time of awakening and stay in the recovery room were shorter (P < .05).
Remazolam combined with sufentanil and propofol has less effect on hemodynamics in painless gastroscopy, and the patients have shorter awakening times.
胃镜检查是上消化道疾病最常用的诊断方法之一。苯磺酸瑞马唑仑是一种新型超短效苯二氮䓬类药物，在胃镜检查中的研究较少。在本研究中，我们探讨了苯磺酸瑞马唑仑联合丙泊酚用于无痛胃镜检查的有效性和安全性。
这是一项单中心、安慰剂对照的随机试验。
本研究纳入100例行无痛胃镜检查的患者，随机分为2组（每组n = 50）：对照组（Con组）和苯磺酸瑞马唑仑组（Rem组）。使用舒芬太尼、苯磺酸瑞马唑仑和丙泊酚对患者进行麻醉，然后比较和分析不同溶液对这些患者的影响。记录患者的一般情况、不同时间的生命体征、丙泊酚用量（mg）及追加次数、并发症、胃镜检查时间（分钟）、苏醒时间（分钟）、在恢复室停留时间（分钟）及不良反应。
Rem组收缩压更稳定（P <.05）。Rem组丙泊酚追加量更少（P <.05）。Rem组低血压、心动过缓和头晕的发生率较低，苏醒时间和在恢复室停留时间也较短（P <.05）。
苯磺酸瑞马唑仑联合舒芬太尼和丙泊酚用于无痛胃镜检查时对血流动力学影响较小，患者苏醒时间较短。
