Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China.
Chengdu Medical College, Chengdu, China.
Medicine (Baltimore). 2023 Sep 1;102(35):e34422. doi: 10.1097/MD.0000000000034422.
Gastroscopy is one of the most commonly used diagnostic modalities for upper gastrointestinal disorders. This study compared the effect of ciprofol and propofol on swallowing function during painless gastroenteroscopy.
This was a single-center, placebo-controlled randomized trial. Three hundred sixty-eight patients undergoing painless gastroscopy were included in this study and randomly divided into 2 groups: the propofol group (PRO group, n = 183) and the ciprofol group (CIP group, n = 185). Sufentanil, ciprofol, and propofol are used to anesthetize the patients, and the effects of different solutions on these patients are compared and analyzed. The patient's general condition, vocal cord adduction reflex, dysphagia severity score, penetration and aspiration scale score, vital signs at different times, complications, recovery time (minutes), residence time in the resuscitation room (minutes), and adverse reactions were recorded.
During the examination, the incidence of severe swallowing dysfunction in CIP group was lower than that in PRO group (P < .05). The BP in CIP group was higher than that in PRO Group (P < .05). The HR of CIP group was lower than that of PRO Group (P < .05). SpO2 in CIP group was higher than that in PRO Group (P < .05). The recovery time of CIP group was longer than that of PRO Group, and the postanesthesia care unit stay time of PRO group was longer than that of CIP group(P < .05). The incidence of respiratory depression, hypotension and cough in CIP group was lower than that in PRO Group (P < .05). The incidence of injection pain in CIP group was lower than that in PRO Group (P < .05).
Compared with propofol, ciprofol has less inhibition on swallowing function, less impact on hemodynamics, less respiratory depression, and less injection pain, which is more suitable for painless gastroscopy.
胃镜检查是上消化道疾病最常用的诊断方法之一。本研究比较了西普罗和丙泊酚对无痛胃镜检查时吞咽功能的影响。
这是一项单中心、安慰剂对照、随机临床试验。本研究纳入 368 例接受无痛胃镜检查的患者，随机分为 2 组：丙泊酚组（PRO 组，n = 183）和西普罗组（CIP 组，n = 185）。舒芬太尼、西普罗和丙泊酚用于麻醉患者，并比较和分析不同溶液对这些患者的影响。记录患者一般情况、声带内收反射、吞咽困难严重程度评分、渗透和吸入量表评分、不同时间的生命体征、并发症、恢复时间（分钟）、复苏室停留时间（分钟）和不良反应。
检查过程中，CIP 组严重吞咽功能障碍的发生率低于 PRO 组（P <.05）。CIP 组的 BP 高于 PRO 组（P <.05）。CIP 组的 HR 低于 PRO 组（P <.05）。CIP 组的 SpO2 高于 PRO 组（P <.05）。CIP 组的恢复时间长于 PRO 组，PRO 组的恢复后护理时间长于 CIP 组（P <.05）。CIP 组呼吸抑制、低血压和咳嗽的发生率低于 PRO 组（P <.05）。CIP 组注射疼痛的发生率低于 PRO 组（P <.05）。
与丙泊酚相比，西普罗对吞咽功能的抑制作用较小，对血液动力学的影响较小，呼吸抑制较少，注射疼痛较少，更适合无痛胃镜检查。
