The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.
Chengdu Medical College, Chengdu, China.
Medicine (Baltimore). 2023 Aug 25;102(34):e34731. doi: 10.1097/MD.0000000000034731.
Gastroscopy is one of the most commonly used diagnostic modalities for upper gastrointestinal disorders. Remazolam besylate, a new type of ultrashort-acting benzodiazepine drug, has been less studied in gastroscopy. In this study, we studied the efficacy and safety of remazolam combined with propofol for painless gastroscopy.
This is a single-center, randomized controlled clinical trial. Hundred patients undergoing painless gastroscopy were included in this study and randomly divided into 2 groups (n = 50 per group): the remazolam 3 mg group (R3 group) and the remazolam 6 mg group (R6 group). Sufentanil, remazolam, and propofol are used to anesthetize the patients, and then, the effects of different dosages of remazolam on these patients are compared and analyzed. The patient's general condition, vital signs at different times, the dosage of propofol (mg) and additional times, complications, duration of gastroscopy (minute), awakening time (minute), residence time in the resuscitation room (minute), and adverse reactions were recorded.
R3 group systolic blood pressure and diastolic blood pressure are more stable (P < .05); The number of additional propofol in R6 group was less (P < .05). The incidence of hypotension was lower in R3 group, as well as the time of awakening and staying in the resuscitation room were shorter (P < .05).
Remazolam 3mg combined with sufentanil and propofol have less effect on hemodynamics in painless gastroscopy, and the patients have shorter awakening time.
胃镜检查是上消化道疾病最常用的诊断方法之一。苯二氮䓬类药物甲磺酸瑞马唑仑是一种新型超短效药物，在胃镜检查中研究较少。本研究旨在研究瑞马唑仑联合丙泊酚用于无痛胃镜的疗效和安全性。
这是一项单中心、随机对照临床试验。本研究纳入 100 例行无痛胃镜检查的患者，随机分为 2 组（每组 50 例）：瑞马唑仑 3mg 组（R3 组）和瑞马唑仑 6mg 组（R6 组）。使用舒芬太尼、瑞马唑仑和丙泊酚对患者进行麻醉，然后比较和分析不同剂量瑞马唑仑对这些患者的影响。记录患者的一般情况、不同时间的生命体征、丙泊酚（mg）的剂量和追加次数、并发症、胃镜检查时间（分钟）、苏醒时间（分钟）、复苏室停留时间（分钟）和不良反应。
R3 组收缩压和舒张压更稳定（P <.05）；R6 组追加丙泊酚的次数较少（P <.05）。R3 组低血压的发生率较低，苏醒时间和复苏室停留时间较短（P <.05）。
瑞马唑仑 3mg 联合舒芬太尼和丙泊酚用于无痛胃镜检查时对血流动力学的影响较小，患者苏醒时间较短。
