Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP), Napoleão de Barros, 925 Vila Clementino, São Paulo, SP, 04024-002, Brazil.
Sleep Institute, São Paulo, SP, Brazil.
Arch Gynecol Obstet. 2024 Sep;310(3):1659-1667. doi: 10.1007/s00404-024-07668-y. Epub 2024 Aug 5.
Our study aimed to identify alterations in sleep, inflammatory mediators, fatigue and quality of life in women with dysmenorrhea and compare them to women without dysmenorrhea.
The sample comprised 328 women from a Brazilian cross-sectional sleep study, EPISONO (2007), who had undergone 1-night polysomnography (PSG) type I and completed questionnaires related to sleep quality, daytime sleepiness, insomnia, fatigue, anxiety, depression, and quality of life. Blood samples were used to assess levels of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP). The 2 groups were distributed based on the presence or absence of dysmenorrhea symptoms.
Sleep efficiency was significantly lower in the group of women with dysmenorrhea (82.5% ± 13.8) compared to the non-dysmenorrhea group (86.2% ± 10.9). Dysmenorrhea was associated with significantly higher scores of fatigue and worse scores in the physical quality of life. No statistical differences were detected in inflammatory markers between the 2 groups.
Fatigue and physical quality of life were presented in women with dysmenorrhea, as was reduced sleep efficiency, although no alteration on inflammatory markers were observed.
These findings show that dysmenorrhea can have a deleterious effect on women's sleep, with repercussions on daily routines and quality of life.
本研究旨在识别痛经女性与非痛经女性在睡眠、炎症介质、疲劳和生活质量方面的变化，并对其进行比较。
本研究样本为巴西一项横断面睡眠研究（EPISONO，2007 年）中的 328 名女性，她们接受了 1 晚的 I 型多导睡眠图（PSG）检查，并完成了与睡眠质量、日间嗜睡、失眠、疲劳、焦虑、抑郁和生活质量相关的问卷。采集血样用于评估白细胞介素 6（IL-6）、肿瘤坏死因子-α（TNF-α）和 C 反应蛋白（CRP）的水平。根据是否存在痛经症状将两组进行分组。
与非痛经组（86.2%±10.9）相比，痛经组女性的睡眠效率（82.5%±13.8）显著降低。痛经与疲劳评分显著升高和身体生活质量评分恶化相关。两组之间的炎症标志物无统计学差异。
痛经患者存在疲劳和身体生活质量下降，睡眠效率降低，尽管炎症标志物没有变化。
这些发现表明，痛经会对女性的睡眠产生不良影响，对日常生活和生活质量产生影响。
