Mahmoud Manal Moustafa, Hassan Mai Mohammed, Elsayed Hany El-Sebaee, Fares Amal E, Saber Mona M, Rashed Laila Ahmed, Abdelwahed Omaima Mohammed
Department of Medical Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Histology & Cell Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Arch Physiol Biochem. 2025 Feb;131(1):94-107. doi: 10.1080/13813455.2024.2387710. Epub 2024 Aug 5.
Type 2 Diabetes mellitus (T2DM) has the potential to impair cardiac function and cause heart failure. We aimed to study the cardioprotective influence of Galactin-3 (Gal-3) inhibitor; modified citrus pectin (MCP) in isoprenaline induced myocardial infarction (MI) in T2DM rats. Forty rats were allocated into 4 groups; groups I and II served as control. T2DM was provoked in groups III and IV by serving them high fat diet followed by a single low dose of Streptozotocin (STZ), then group IV were administered MCP in drinking water for 6 weeks. Groups III and IV were then subcutaneously injected isoprenaline hydrochloride once daily on the last 2 successive days to induce MI. MCP restored echocardiographic parameters with significant decline in Gal-3 area % in cardiac tissue alongside protection against cardiac remodelling. our data showed that there is a protective potential for Gal-3 inhibitor (MCP) against cardiac injury in isoprenaline induced MI in T2DM.
2型糖尿病（T2DM）有可能损害心脏功能并导致心力衰竭。我们旨在研究半乳糖凝集素-3（Gal-3）抑制剂——改性柑橘果胶（MCP）对异丙肾上腺素诱导的T2DM大鼠心肌梗死（MI）的心脏保护作用。40只大鼠被分为4组；第一组和第二组作为对照组。第三组和第四组通过给予高脂饮食，随后单次低剂量链脲佐菌素（STZ）诱导T2DM，然后第四组在饮用水中给予MCP 6周。在连续的最后2天，第三组和第四组每天皮下注射一次盐酸异丙肾上腺素以诱导MI。MCP恢复了超声心动图参数，心脏组织中Gal-3面积百分比显著下降，同时防止了心脏重塑。我们的数据表明，Gal-3抑制剂（MCP）对异丙肾上腺素诱导的T2DM大鼠MI中的心脏损伤具有保护潜力。
