Lipworth L, Tiarks C Y, Rice C A, Pechet L
Am J Clin Pathol. 1979 Dec;72(6):1000-4. doi: 10.1093/ajcp/72.6.1000.
The authors studied the effect of averaging replicated assays of Factor IX coagulation activity and Factor IX antigen on each plasma specimen in improving the ability to detect carriers of hemophilia B. The improvement resulting from this procedure is particularly marked in tests depending on the linear regression of one characteristic on another to diagnose the carrier state. The effects of averaging assays on the ratio of Factor IX coagulation activity to Factor IX antigen were also explored. The benefits of averaging replications were not greatly increased by use of more than four replications.
作者研究了对每份血浆标本的凝血因子IX活性和凝血因子IX抗原的重复检测结果进行平均，对提高检测B型血友病携带者能力的影响。在依靠一种特性对另一种特性进行线性回归来诊断携带者状态的检测中，这一程序带来的改善尤为显著。还探讨了检测结果平均化对凝血因子IX活性与凝血因子IX抗原比值的影响。重复检测超过四次后，平均化检测带来的益处并未大幅增加。
