大剂量红霉素联合标准剂量氯喹或奎宁治疗恶性疟失败。
Failure of large-dose erythromycin in combination with a standard dose of chloroquine or quinine in the treatment of human falciparum malaria.
作者信息
Pang L W, Boudreau E F, Childs G E, Webster H K, Supanantalerk C, Somutsakorn P
出版信息
Bull World Health Organ. 1985;63(4):739-43.
In eastern Thailand, falciparum malaria is highly chloroquine-resistant and is quickly becoming quinine-resistant. In the present study, ten patients with falciparum malaria were given large doses of erythromycin, combined with standard doses of chloroquine; the cure rate was 0 out of 10 (4 RIII failures, 6 RII failures). A further ten patients were given erythromycin with standard doses of quinine; 2 of the 10 patients were cured (8 RI failures). These regimens thus appear to have no appreciable effect against falciparum infections in eastern Thailand.
在泰国东部，恶性疟原虫对氯喹具有高度耐药性，并且对奎宁的耐药性正在迅速形成。在本研究中，10例恶性疟患者接受了大剂量红霉素与标准剂量氯喹联合治疗；治愈率为10例中0例（4例为RIII级失败，6例为RII级失败）。另外10例患者接受了红霉素与标准剂量奎宁联合治疗；10例患者中有2例治愈（8例为RI级失败）。因此，这些治疗方案对泰国东部的恶性疟感染似乎没有明显效果。
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