放射性肺损伤的发病机制及最新治疗方法：综述。
Pathogenic mechanisms and latest therapeutic approaches for radiation-induced lung injury: A narrative review.
机构信息
Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Department of Radiation Oncology, the First Hospital of Jilin University, Changchun 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130021, China.
Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China.
出版信息
Crit Rev Oncol Hematol. 2024 Oct;202:104461. doi: 10.1016/j.critrevonc.2024.104461. Epub 2024 Aug 3.
The treatment of thoracic tumors with ionizing radiation can cause radiation-induced lung injury (RILI), which includes radiation pneumonitis and radiation-induced pulmonary fibrosis. Preventing RILI is crucial for controlling tumor growth and improving quality of life. However, the serious adverse effects of traditional RILI treatment methods remain a major obstacle, necessitating the development of novel treatment options that are both safe and effective. This review summarizes the molecular mechanisms of RILI and explores novel treatment options, including natural compounds, gene therapy, nanomaterials, and mesenchymal stem cells. These recent experimental approaches show potential as effective prevention and treatment options for RILI in clinical practice.
胸部肿瘤的电离辐射治疗可引起放射性肺损伤（RILI），包括放射性肺炎和放射性肺纤维化。预防 RILI 对于控制肿瘤生长和提高生活质量至关重要。然而，传统 RILI 治疗方法的严重不良反应仍是主要障碍，需要开发安全有效的新型治疗选择。本综述总结了 RILI 的分子机制，并探讨了包括天然化合物、基因治疗、纳米材料和间充质干细胞在内的新型治疗选择。这些最近的实验方法显示出在临床实践中作为 RILI 有效预防和治疗选择的潜力。
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