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用于心血管工程的供氧生物材料:揭示未来的发现。

Oxygen-generating biomaterials for cardiovascular engineering: unveiling future discoveries.

机构信息

Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.

Clinic of Vascular and Endovascular Surgery, RWTH Aachen University Hospital, Aachen, Germany.

出版信息

Drug Discov Today. 2024 Sep;29(9):104135. doi: 10.1016/j.drudis.2024.104135. Epub 2024 Aug 3.

Abstract

Oxygen-generating biomaterials are emerging as a groundbreaking solution for transforming cardiovascular engineering. These biomaterials generate and release oxygen within various biomedical applications, marking a new frontier in healthcare. Most cardiovascular treatments face a significant challenge, ensuring a consistent oxygen supply to nurture engineered tissues or even implanted devices. Traditional methods relying on passive oxygen diffusion often fall short, hindering functional cardiovascular tissue development. Oxygen-generating biomaterials, incorporating agents like calcium peroxide, provide a controlled oxygen source to the surrounding cells. This innovation potentially enhances cell viability, stimulates growth and boosts metabolic activity crucial for tissue health. Applications include repairing cardiac and vascular tissues, disease modeling, drug testing and personalized medicine, promising tailored treatments. Challenges like material toxicity and oxygen release control need consideration. As research progresses, the use of these innovative biomaterials in clinical translation could reshape cardiovascular healthcare, revolutionizing patient outcomes in heart disease treatment.

摘要

供氧生物材料在心血管工程领域崭露头角,为其带来变革。这些生物材料在各种生物医学应用中生成并释放氧气,为医疗保健开创了全新领域。大多数心血管治疗都面临着一个重大挑战,即确保为工程组织或甚至植入设备持续提供充足氧气。传统的被动氧扩散方法往往效果不佳,阻碍了功能性心血管组织的发展。而利用过氧化钙等制剂的供氧生物材料可为周围细胞提供受控的氧气源。这一创新极大地提高了细胞活力,刺激了生长并增强了新陈代谢活动,对组织健康至关重要。其应用包括修复心脏和血管组织、疾病建模、药物测试和个性化医疗,有望实现针对性治疗。但仍需考虑材料毒性和氧气释放控制等挑战。随着研究的进展,这些创新型生物材料在临床转化中的应用有望重塑心血管医疗保健,彻底改变心脏病治疗的患者预后。

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