一种用于肿瘤细胞成像和杀伤的顺序双锁发光铜纳米团簇探针。
A sequential dual-locked luminescent copper nanocluster probe for tumor cell imaging and killing.
机构信息
State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China.
Institute of Applied Chemistry, School of Science, Central South University of Forestry and Technology, Changsha, 410004, People's Republic of China.
出版信息
Mikrochim Acta. 2024 Aug 5;191(9):511. doi: 10.1007/s00604-024-06591-y.
A sequential dual-locked luminescent copper nanoclusters (CuNCs) probe was designed and synthesized for the specific imaging and selective killing of tumor cells. This nanoprobe was prepared by first forming a Fe-coupled tannic acid (TA)-stabilized CuNCs (CuNCs-Fe), which is in quenching state due to the electron transfer between CuNCs and Fe, and then coating a protectable layer of hyaluronic acid (HA) on the surface of CuNCs-Fe to form the final dual-locked nanoprobe (CuNCs-Fe@HA). When the nanoprobe of CuNCs-Fe@HA target enter the tumor cells through CD44-HA receptor, HAase will first digest the HA layer of the nanoprobes, and then, GSH over-expressed in tumor cells will reduce Fe to Fe, thus restoring the fluorescence emission of CuNCs and at the same time killing the tumor cells with the hydroxyl free radicals (∙OH) produced by the Fenton reaction between Fe and HO. This sequential dual-locked luminescent nanoprobe of CuNCs-Fe@HA has been successfully used for the specific imaging and selective killing of tumor cells.
一种顺序双锁亮铜纳米团簇（CuNCs）探针被设计并合成用于肿瘤细胞的特异性成像和选择性杀伤。该纳米探针通过首先形成一个 Fe 偶联的单宁酸（TA）稳定的 CuNCs（CuNCs-Fe）来制备，由于 CuNCs 和 Fe 之间的电子转移，CuNCs-Fe 处于猝灭状态，然后在 CuNCs-Fe 的表面涂覆一层可保护的透明质酸（HA）形成最终的双锁纳米探针（CuNCs-Fe@HA）。当靶向 CuNCs-Fe@HA 的纳米探针通过 CD44-HA 受体进入肿瘤细胞时，HAase 首先会消化纳米探针的 HA 层，然后，肿瘤细胞中过表达的 GSH 会将 Fe 还原为 Fe，从而恢复 CuNCs 的荧光发射，同时利用 Fe 和 HO 之间的 Fenton 反应产生的羟基自由基（∙OH）杀死肿瘤细胞。这种顺序双锁亮的 CuNCs-Fe@HA 纳米探针已成功用于肿瘤细胞的特异性成像和选择性杀伤。
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