Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.
Division of Animal Sciences, University of Missouri, Columbia, MO, USA.
Nat Genet. 2024 Aug;56(8):1566-1573. doi: 10.1038/s41588-024-01835-2. Epub 2024 Aug 5.
Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the 'Ruminant T2T Consortium' (RT2T), that aims to generate complete diploid assemblies for numerous species of the Artiodactyla suborder Ruminantia to examine chromosomal evolution in the context of natural selection and domestication of species used as livestock.
端粒到端粒(T2T)组装揭示了对之前“不可见”基因组部分的结构和功能的新见解,并允许在整个进化枝中对完整基因组进行比较分析。我们在这里提出了一个开放的协作努力,称为“反刍动物 T2T 联盟”(RT2T),旨在为反刍亚目偶蹄目动物的许多物种生成完整的二倍体组装,以研究在自然选择和作为家畜使用的物种驯化的背景下的染色体进化。