LOEWE Centre for Translational Biodiversity Genomics, Senckenberg Biodiversity and Climate Research Centre, Georg-Voigt-Str. 14-16, 60325 Frankfurt/Main, Germany.
CE3C - Centre for Ecology, Evolution and Environmental Changes & CHANGE - Global Change and Sustainability Institute, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal; Faculdade de Psicologia, Universidade de Lisboa, Alameda da Universidade, 1649-013 Lisboa, Portugal.
Trends Genet. 2023 Jul;39(7):545-559. doi: 10.1016/j.tig.2023.01.005. Epub 2023 Feb 16.
The availability of public genomic resources can greatly assist biodiversity assessment, conservation, and restoration efforts by providing evidence for scientifically informed management decisions. Here we survey the main approaches and applications in biodiversity and conservation genomics, considering practical factors, such as cost, time, prerequisite skills, and current shortcomings of applications. Most approaches perform best in combination with reference genomes from the target species or closely related species. We review case studies to illustrate how reference genomes can facilitate biodiversity research and conservation across the tree of life. We conclude that the time is ripe to view reference genomes as fundamental resources and to integrate their use as a best practice in conservation genomics.
公共基因组资源的可用性可以通过为科学决策提供依据,极大地帮助生物多样性评估、保护和恢复工作。在这里,我们调查了生物多样性和保护基因组学中的主要方法和应用,考虑了成本、时间、先决技能以及应用的当前缺点等实际因素。大多数方法与目标物种或密切相关物种的参考基因组结合使用时效果最佳。我们审查了案例研究,以说明参考基因组如何促进整个生命之树的生物多样性研究和保护。我们的结论是,现在是将参考基因组视为基本资源并将其作为保护基因组学的最佳实践进行整合的时候了。