Department of Neurology, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistraße 15, Munich, 81377, Germany.
Department of Neurosurgery, UTHealth Houston, Houston, TX, USA.
J Headache Pain. 2024 Aug 5;25(1):128. doi: 10.1186/s10194-024-01838-8.
Cluster headache (CH) is associated with high disability. The Cluster Headache Impact Questionnaire (CHIQ) is a short, disease-specific disability questionnaire first developed and validated in German. Here, we validated the English version of this questionnaire.
The CHIQ was assessed together with nonspecific headache-related disability questionnaires in CH patients from a tertiary headache center and an American self-help group.
155 active episodic and chronic CH patients were included. The CHIQ showed good internal consistency (Cronbach's α = 0.91) and test-retest reliability (ICC = 0.93, n = 44). Factor analysis identified a single factor. Convergent validity was shown by significant correlations with the Headache Impact Test™ (HIT-6™, ρ = 0.72, p < 0.001), the Hospital Anxiety and Depression Scale (HADS depression: ρ = 0.53, HADS anxiety: ρ = 0.61, both p < 0.001), the Perceived Stress Scale (PSS-10, ρ = 0.61, p < 0.001) and with CH attack frequency (ρ = 0.29, p < 0.001). Chronic CH patients showed the highest CHIQ scores (25.4 ± 7.9, n = 76), followed by active episodic CH and episodic CH patients in remission (active eCH: 22.2 ± 8.7, n = 79; eCH in remission: 14.1 ± 13.1, n = 127; p < 0.001). Furthermore, the CHIQ was graded into 5 levels from "no to low impact" to "extreme impact" based on the patients' perception. Higher CHIQ grading was associated with higher attack and acute medication frequency, HIT-6™, HADS and PSS scores.
The English version of the CHIQ is a reliable, valid, and disease-specific patient-reported outcome measure to assess the impact of headaches on CH patients.
丛集性头痛（CH）与高残疾相关。《丛集性头痛影响问卷》（CHIQ）是一种简短的、针对特定疾病的残疾问卷，最初在德国开发并验证。在这里，我们验证了该问卷的英文版本。
在一家三级头痛中心和一个美国自助小组的丛集性头痛患者中，同时评估 CHIQ 与非特异性头痛相关残疾问卷。
共纳入 155 例活动性发作性和慢性 CH 患者。CHIQ 显示出良好的内部一致性（Cronbach's α = 0.91）和重测信度（ICC = 0.93，n = 44）。因子分析确定了一个单一因素。与 Headache Impact Test™（HIT-6™，ρ = 0.72，p < 0.001）、医院焦虑和抑郁量表（HADS 抑郁：ρ = 0.53，HADS 焦虑：ρ = 0.61，均 p < 0.001）、感知压力量表（PSS-10，ρ = 0.61，p < 0.001）和 CH 发作频率（ρ = 0.29，p < 0.001）的显著相关性表明了其具有良好的聚合效度。慢性 CH 患者的 CHIQ 评分最高（25.4 ± 7.9，n = 76），其次是活动性发作性 CH 和缓解期的发作性 CH 患者（活动性 eCH：22.2 ± 8.7，n = 79；缓解期 eCH：14.1 ± 13.1，n = 127；p < 0.001）。此外，根据患者的感知，将 CHIQ 分为从“无到低影响”到“极度影响”的 5 个等级。更高的 CHIQ 分级与更高的发作和急性药物治疗频率、HIT-6™、HADS 和 PSS 评分相关。
CHIQ 的英文版本是一种可靠、有效的、针对特定疾病的患者报告结局测量工具，可用于评估头痛对 CH 患者的影响。
