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Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine, a melatonin metabolite, in the hippocampus: a potential prophylactic agent for dementia.

作者信息

Watanabe Kazuki, Hattori Atsuhiko

机构信息

Department of Immunobiology, Institute of Development Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan (Watanabe K).

Department of Sport and Wellness, College of Sport and Wellness, Rikkyo University, Niiza, Saitama, Japan (Hattori A).

出版信息

Neural Regen Res. 2025 Jun 1;20(6):1705-1706. doi: 10.4103/NRR.NRR-D-24-00379. Epub 2024 Jul 10.

DOI:10.4103/NRR.NRR-D-24-00379
PMID:39104103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688570/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e361/11688570/c5caf7557a39/NRR-20-1705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e361/11688570/c5caf7557a39/NRR-20-1705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e361/11688570/c5caf7557a39/NRR-20-1705-g001.jpg

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1
Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine, a melatonin metabolite, in the hippocampus: a potential prophylactic agent for dementia.衰老导致海马体中褪黑素代谢产物N1-乙酰-5-甲氧基犬尿胺减少而引起记忆丧失：一种潜在的痴呆症预防药物。
Neural Regen Res. 2025 Jun 1;20(6):1705-1706. doi: 10.4103/NRR.NRR-D-24-00379. Epub 2024 Jul 10.
2
N1-Acetyl-5-methoxykynuramine, which decreases in the hippocampus with aging, improves long-term memory via CaMKII/CREB phosphorylation.N1-乙酰-5-甲氧基犬尿氨酸随着年龄的增长而减少，通过 CaMKII/CREB 磷酸化改善长期记忆。
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The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term object memory in young and aging mice.褪黑素代谢物 N1-乙酰-5-甲氧基犬尿氨酸促进年轻和衰老小鼠的长期物体记忆。
J Pineal Res. 2021 Jan;70(1):e12703. doi: 10.1111/jpi.12703. Epub 2020 Nov 20.
4
Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages.褪黑素及其代谢产物N1-乙酰基-N2-甲酰基-5-甲氧基犬尿胺（AFMK）和N1-乙酰基-5-甲氧基犬尿胺（AMK）在巨噬细胞中的抗炎作用。
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Novel pathway for N1-acetyl-5-methoxykynuramine: UVB-induced liberation of carbon monoxide from precursor N1-acetyl-N2-formyl-5-methoxykynuramine.N1-乙酰-5-甲氧基犬尿胺的新途径：紫外线B诱导一氧化碳从前体N1-乙酰-N2-甲酰基-5-甲氧基犬尿胺中释放。
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6
Oxidation of melatonin and its catabolites, N1-acetyl-N2 -formyl-5-methoxykynuramine and N1-acetyl-5-methoxykynuramine, by activated leukocytes.褪黑素及其代谢产物N1-乙酰基-N2-甲酰基-5-甲氧基犬尿胺和N1-乙酰基-5-甲氧基犬尿胺被活化白细胞氧化。
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Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction.褪黑素代谢产物N1-乙酰基-5-甲氧基犬尿胺（AMK）的抗氧化特性：清除自由基和防止蛋白质破坏。
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Synthesis of internal labeled standards of melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine for their quantification using an on-line liquid chromatography-electrospray tandem mass spectrometry system.褪黑素及其代谢物N1-乙酰基-N2-甲酰基-5-甲氧基犬尿胺内标物的合成，用于通过在线液相色谱-电喷雾串联质谱系统进行定量分析。
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[Gandou Bushen Decoction Ameliorates Cognitive Impairment in Wilson Disease Model TX Mice by Regulating Melatonin Synthesis via the SIRT3/FOXO3α Pathway].[甘豆补肾汤通过SIRT3/FOXO3α通路调节褪黑素合成改善威尔逊病模型TX小鼠的认知障碍]
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本文引用的文献

1
Receptor-Mediated and Receptor-Independent Actions of Melatonin in Vertebrates.脊椎动物褪黑素的受体介导和非受体依赖性作用。
Zoolog Sci. 2024 Feb;41(1):105-116. doi: 10.2108/zs230057.
2
N1-Acetyl-5-methoxykynuramine, which decreases in the hippocampus with aging, improves long-term memory via CaMKII/CREB phosphorylation.N1-乙酰-5-甲氧基犬尿氨酸随着年龄的增长而减少，通过 CaMKII/CREB 磷酸化改善长期记忆。
J Pineal Res. 2024 Jan;76(1):e12934. doi: 10.1111/jpi.12934.
3
Nocturnal melatonin increases glucose uptake via insulin-independent action in the goldfish brain.
夜间褪黑素通过非胰岛素依赖作用增加金鱼大脑中的葡萄糖摄取。
Front Endocrinol (Lausanne). 2023 May 23;14:1173113. doi: 10.3389/fendo.2023.1173113. eCollection 2023.
4
Melatonin levels in the Alzheimer's disease continuum: a systematic review.阿尔茨海默病连续体中的褪黑素水平：系统评价。
Alzheimers Res Ther. 2021 Feb 23;13(1):52. doi: 10.1186/s13195-021-00788-6.
5
The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term object memory in young and aging mice.褪黑素代谢物 N1-乙酰-5-甲氧基犬尿氨酸促进年轻和衰老小鼠的长期物体记忆。
J Pineal Res. 2021 Jan;70(1):e12703. doi: 10.1111/jpi.12703. Epub 2020 Nov 20.
6
Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection.褪黑素及其代谢产物与氧化应激：从个体作用到集体保护。
J Pineal Res. 2018 Aug;65(1):e12514. doi: 10.1111/jpi.12514.
7
Administration of exogenous melatonin increases spreading activation in lexical memory networks.外源性褪黑素的施用增加了词汇记忆网络中的扩散激活。
Hum Psychopharmacol. 2014 Jul;29(4):397-404. doi: 10.1002/hup.2416.
8
Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease.胰岛素可逆转高脂肪饮食诱导的大脑 Aβ增加，并改善阿尔茨海默病动物模型的记忆。
Diabetes. 2014 Dec;63(12):4291-301. doi: 10.2337/db14-0375. Epub 2014 Jul 9.
9
Melatonin metabolism in the central nervous system.中枢神经系统中的褪黑素代谢。
Curr Neuropharmacol. 2010 Sep;8(3):168-81. doi: 10.2174/157015910792246244.