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Remaking a connection: molecular players involved in post-injury synapse formation.

作者信息

Tomé Diogo, Almeida Ramiro D

机构信息

iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal (Tomé D, Almeida RD).

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal (Tomé D, Almeida RD).

出版信息

Neural Regen Res. 2025 Jun 1;20(6):1719-1720. doi: 10.4103/NRR.NRR-D-24-00265. Epub 2024 Jun 26.

DOI:10.4103/NRR.NRR-D-24-00265
PMID:39104110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688557/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/11688557/f6ace8e7dfa4/NRR-20-1719-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/11688557/f6ace8e7dfa4/NRR-20-1719-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3e/11688557/f6ace8e7dfa4/NRR-20-1719-g001.jpg

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本文引用的文献

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Microglia and astrocytes mediate synapse engulfment in a MER tyrosine kinase-dependent manner after traumatic brain injury.在创伤性脑损伤后，小胶质细胞和星形胶质细胞以MER酪氨酸激酶依赖性方式介导突触吞噬。
Neural Regen Res. 2023 Aug;18(8):1770-1776. doi: 10.4103/1673-5374.363187.
2
Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury.成突触基因治疗联合 FGF22 可改善脊髓损伤后的回路可塑性和功能恢复。
EMBO Mol Med. 2023 Feb 8;15(2):e16111. doi: 10.15252/emmm.202216111. Epub 2023 Jan 5.
3
An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.
活跃的囊泡引发机制抑制成年中枢神经系统损伤后的轴突再生。
Neuron. 2022 Jan 5;110(1):51-69.e7. doi: 10.1016/j.neuron.2021.10.007. Epub 2021 Oct 26.
4
Axon Regeneration: A Subcellular Extension in Multiple Dimensions.轴突再生：多个维度的亚细胞延伸。
Cold Spring Harb Perspect Biol. 2022 Mar 1;14(3):a040923. doi: 10.1101/cshperspect.a040923.
5
Emerging roles for α2δ subunits in calcium channel function and synaptic connectivity.α2δ 亚基在钙通道功能和突触连接中的新兴作用。
Curr Opin Neurobiol. 2020 Aug;63:162-169. doi: 10.1016/j.conb.2020.04.007. Epub 2020 Jun 7.
6
Injured adult neurons regress to an embryonic transcriptional growth state.成年受损神经元退回到胚胎转录生长状态。
Nature. 2020 May;581(7806):77-82. doi: 10.1038/s41586-020-2200-5. Epub 2020 Apr 15.
7
Moving beyond the glial scar for spinal cord repair.超越脊髓修复的神经胶质瘢痕。
Nat Commun. 2019 Aug 28;10(1):3879. doi: 10.1038/s41467-019-11707-7.
8
Neurotoxic reactive astrocytes are induced by activated microglia.神经毒性反应性星形胶质细胞由活化的小胶质细胞诱导产生。
Nature. 2017 Jan 26;541(7638):481-487. doi: 10.1038/nature21029. Epub 2017 Jan 18.
9
Puzzling out presynaptic differentiation.破解突触前分化之谜。
J Neurochem. 2016 Dec;139(6):921-942. doi: 10.1111/jnc.13702. Epub 2016 Jul 28.
10
Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury.阻断星形胶质细胞的钙调神经磷酸酶/活化T细胞核因子信号通路有助于使创伤性脑损伤大鼠模型的海马突触功能和可塑性恢复正常。
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