Thammahong Arsa, Sukswai Narittee, Polprasert Chantana
Department of Medicine Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Center of Excellence in Antimicrobial Resistance and Stewardship Department of Microbiology Faculty of Medicine Chulalongkorn University, Bangkok, Thailand.
Case Rep Hematol. 2024 Jul 24;2024:7310135. doi: 10.1155/2024/7310135. eCollection 2024.
T-cell prolymphocytic leukemia (T-PLL) is a rare, mature T-cell leukemia which usually presents with aggressive behavior. We report an asymptomatic T-PLL patient diagnosed by clinical features, lymphocyte morphology, and flow cytometry. Incidentally, she was found to have lymphocytosis and lymphadenopathy. Flow cytometry from blood revealed an abnormally increased CD4+ T-cell population. T-cell receptor clonality assessment by next-generation sequencing revealed a dominant clone in the ß-chain constant region. No pathogenic mutations in 25 lymphoma-related genes were found. Due to her asymptomatic T-PLL disease, we observed her clinical situation and blood count every three months for at least one year.
T 细胞幼淋巴细胞白血病（T-PLL）是一种罕见的成熟 T 细胞白血病，通常具有侵袭性。我们报告了一例通过临床特征、淋巴细胞形态学和流式细胞术诊断的无症状 T-PLL 患者。偶然发现，她存在淋巴细胞增多和淋巴结病。血液流式细胞术显示 CD4+ T 细胞群体异常增加。通过下一代测序进行的 T 细胞受体克隆性评估显示在β链恒定区存在一个优势克隆。未发现 25 个淋巴瘤相关基因的致病突变。由于她的无症状 T-PLL 疾病，我们至少一年每三个月观察一次她的临床情况和血细胞计数。
