Schjørring Christel Baagø, Eddelien Heidi Shil, Butt Jawad Haider, Kruuse Christina
Department of Neurology, Neurovascular Research Unit, Copenhagen University Hospital, Herlev and Gentofte, Copenhagen, Denmark.
Institute of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.
BMJ Neurol Open. 2024 Aug 1;6(2):e000795. doi: 10.1136/bmjno-2024-000795. eCollection 2024.
Erectile dysfunction (ED) and stroke share common risk factors, and symptoms of ED often precede the development of clinical cardiovascular disease (CVD). However, little is known about how ED is associated with cardiovascular (CV) risk factors in patients who had a stroke and if concomitant ED is a marker of more severe CVD.
We aimed to identify the prevalence of ED and CV risk factors in patients admitted with a stroke or transient ischaemic attack (TIA). Further, we wanted to test if self-reported ED associated with presence of CV risk factors, and if patients with ED had increased stroke severity compared with patients without ED.
This was a post hoc analysis of data retrieved in a cross-sectional survey from two non-comprehensive stroke units in Denmark. Multiple logistic regression adjusted for covariates was performed to investigate the association between CV risk factors and self-reported ED.
We included 287 male patients of which 116 (40.4%) had self-reported ED. Advanced age was significantly associated with self-reported ED (reference ≤60 years: OR 3.93, 95% CI 1.84 to 8.37 for men 71-80 years and OR 4.61, 95% CI 1.92 to 11.08 for men >80 years). Self-reported ED was not significantly associated with CV risk factors or stroke severity.
Four in 10 men with acute stroke or TIA reported to have ED prior to their stroke, and this was associated with age rather than CV risk factors. Hence, self-reported ED was not restricted to the CVD load, nor was ED a risk marker for increased stroke severity. However, our population was of high age with well-established CVD, and the presence of ED may be a stroke risk marker in younger patients who had a stroke. Based on the prevalence, potential treatment of ED should be addressed in stroke recovery.
勃起功能障碍（ED）与中风有共同的风险因素，且ED症状往往先于临床心血管疾病（CVD）出现。然而，对于中风患者中ED如何与心血管（CV）风险因素相关联，以及伴发的ED是否是更严重CVD的标志，人们知之甚少。
我们旨在确定中风或短暂性脑缺血发作（TIA）住院患者中ED和CV风险因素的患病率。此外，我们想检验自我报告的ED是否与CV风险因素的存在相关，以及与无ED的患者相比，有ED的患者中风严重程度是否增加。
这是一项对从丹麦两个非综合性中风单元的横断面调查中检索到的数据进行的事后分析。进行了调整协变量的多重逻辑回归，以研究CV风险因素与自我报告的ED之间的关联。
我们纳入了287名男性患者，其中116名（40.4%）自我报告有ED。高龄与自我报告的ED显著相关（参考年龄≤60岁：71 - 80岁男性的OR为3.93，95%CI为1.84至8.37；>80岁男性的OR为4.61，95%CI为1.9%至11.08）。自我报告的ED与CV风险因素或中风严重程度无显著关联。
10名急性中风或TIA男性患者中有4名报告在中风前有ED，这与年龄相关而非CV风险因素。因此，自我报告的ED不仅限于CVD负荷，也不是中风严重程度增加的风险标志物。然而，我们的研究人群年龄较大且CVD已确诊，在年轻的中风患者中，ED的存在可能是中风风险标志物。基于患病率，应在中风康复中考虑对ED进行潜在治疗。
