Zhang Jie, Liang Depeng, Xu Lidong, Liu Yanhong, Jiang Shan, Han Xiaomeng, Wu Huili, Jiang Yuanyuan
Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Henan Provincial Medicine Key Laboratory of Colorectal Cancer Diagnosis and Treatment, Zhengzhou, China.
Front Nutr. 2024 Jul 22;11:1428488. doi: 10.3389/fnut.2024.1428488. eCollection 2024.
Traditional anthropometric measures, including body mass index (BMI), are insufficient for evaluating gallstone risk. This study investigated the association between novel anthropometric indices and gallstone risk among 6,848 participants from the National Health and Nutrition Examination Survey in the United States.
Measures calculated included weight (WT), BMI, waist circumference (WC), waist-to-height ratio (WtHR), conicity index (CI), A Body Shape Index (ABSI), Body Roundness Index (BRI), Abdominal Volume Index (AVI), and Weight-adjusted Waist Index (WWI). Logistic regression and smooth curve fitting assessed the relationships between these indices and gallstones, complemented by receiver operating characteristic (ROC) curve analysis to evaluate their discriminative power.
The results indicated significant differences between study groups, with a positive and independent correlation identified between gallstones and all measures except ABSI. Specifically, per 1 SD increase in WC, WT, BMI, WtHR, and AVI was associated with a 57%, 59%, 52%, 53%, and 53% increased risk of gallstones, respectively. Dose-response analysis confirmed a positive correlation between these indices and gallstone risk. ROC analysis highlighted WtHR and BRI as having superior discriminative abilities (AUC = 0.6703). Further, among participants with a BMI < 30 kg/m2, elevated levels of WT, WtHR, CI, BRI, and WWI significantly increased the risk of gallstones ( < 0.001). Likewise, elevated BMI heightened the risk at low levels of WT, WC, WtHR, BRI, AVI, and CI ( < 0.001).
This study supports the positive association between various anthropometric indicators and gallstones, recommending that newer anthropometric indices be considered more extensively to enhance gallstone prevention and treatment strategies.
包括体重指数（BMI）在内的传统人体测量方法不足以评估胆结石风险。本研究在美国国家健康与营养检查调查的6848名参与者中，调查了新型人体测量指数与胆结石风险之间的关联。
计算的测量指标包括体重（WT）、BMI、腰围（WC）、腰高比（WtHR）、锥度指数（CI）、A体型指数（ABSI）、身体圆度指数（BRI）、腹部容积指数（AVI）和体重调整腰围指数（WWI）。逻辑回归和平滑曲线拟合评估了这些指数与胆结石之间的关系，并通过受试者工作特征（ROC）曲线分析来评估它们的判别能力。
结果表明研究组之间存在显著差异，除ABSI外，胆结石与所有测量指标之间均存在正相关且独立相关。具体而言，WC、WT、BMI、WtHR和AVI每增加1个标准差，胆结石风险分别增加57%、59%、52%、53%和53%。剂量反应分析证实了这些指数与胆结石风险之间存在正相关。ROC分析突出显示WtHR和BRI具有更好的判别能力（AUC = 0.6703）。此外，在BMI < 30 kg/m²的参与者中，WT、WtHR、CI、BRI和WWI水平升高显著增加了胆结石风险（< 0.001）。同样，在WT、WC、WtHR、BRI、AVI和CI水平较低时，BMI升高会增加风险（< 0.001）。
本研究支持各种人体测量指标与胆结石之间的正相关关系，建议更广泛地考虑使用更新的人体测量指数，以加强胆结石的预防和治疗策略。
