Yang Yiling, Shi Xiaomin, Wang Xiaohong, Huang Shu, Xu Jia, Xin Chen, Li Ziyan, Wang Yizhou, Ye Yusong, Liu Sha, Zhang Wei, Lv Muhan, Tang Xiaowei
Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan, China.
Department of Gastroenterology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, China.
Sci Rep. 2025 May 22;15(1):17843. doi: 10.1038/s41598-025-02598-4.
The Body Rounds Index (BRI) is an anthropometric indicator specifically developed to evaluate an individual's obesity level, particularly emphasizing central or abdominal obesity. This study aimed to explore the relationship between BRI and all-cause mortality in older U.S. adults. The research sample comprised individuals aged 65 and older from the National Health and Nutrition Examination Survey (NHANES), eligible for mortality analyses between 1999 and 2018. We utilized Cox regression analyses, restricted cubic spline (RCS), threshold effects analysis, Kaplan-Meier curves, and subgroup analyses were conducted to assess how the BRI correlates with all-cause mortality among older adults in the U.S. To further ensure the robustness of our findings, we conducted sensitivity analyses. Among 5371 U.S. older adults (age ≥ 65), with an average age of 72.45 (standard deviation [SD]:5.65) years, 2884 (60%) were women. During the follow-up period, there were 2781 deaths from all causes among the 5371 participants. After adjusting for all covariates, a U-shaped association was identified between BRI and the all cause mortality. Compared to a BRI of less than 4.457, a BRI between 4.457 and 5.538 was associated with a 19% reduction in the likelihood of mortality from any cause (HR = 0.81, 95% CI = 0.69-0.95). A BRI between 5.538 and 6.888 was linked to a 8% reduction in mortality risk (HR = 0.92, 95% CI = 0.79-1.07), while a BRI exceeding 6.888 showed a 1% increase in this risk (HR = 1.01, 95% CI = 0.87-1.17). RCS analysis indicated a U-shaped relationship between BRI and all-cause mortality. The turning point was located at 4.546, with correlations observed both before and after this point. This NHANES-based study highlights the U-shaped relationship between BRI and all-cause mortality among U.S. older adults, suggesting that the BRI has predictive value for mortality outcomes. The findings offer compelling support for utilizing BRI as a non-invasive mortality risk screening tool.
身体围度指数（BRI）是一项专门为评估个体肥胖程度而开发的人体测量指标，尤其侧重于中心性肥胖或腹部肥胖。本研究旨在探讨BRI与美国老年成年人全因死亡率之间的关系。研究样本包括来自美国国家健康与营养检查调查（NHANES）的65岁及以上个体，这些个体在1999年至2018年间符合死亡率分析条件。我们采用Cox回归分析、受限立方样条（RCS）分析、阈值效应分析、Kaplan-Meier曲线分析，并进行亚组分析，以评估BRI与美国老年成年人全因死亡率之间的相关性。为进一步确保研究结果的稳健性，我们进行了敏感性分析。在5371名美国老年成年人（年龄≥65岁）中，平均年龄为72.45岁（标准差[SD]：5.65），其中2884名（60%）为女性。在随访期间，5371名参与者中有2781人死于各种原因。在对所有协变量进行调整后，发现BRI与全因死亡率之间呈U形关联。与BRI小于4.457相比，BRI在4.457至5.538之间与任何原因导致的死亡可能性降低19%相关（风险比[HR]=0.81，95%置信区间[CI]=0.69-0.95）。BRI在5.538至6.888之间与死亡风险降低8%相关（HR=0.92，95%CI=0.79-1.07），而BRI超过6.888则显示该风险增加1%（HR=1.01，95%CI=0.87-1.17）。RCS分析表明BRI与全因死亡率之间呈U形关系。转折点位于4.546，在此点前后均观察到相关性。这项基于NHANES的研究突出了BRI与美国老年成年人全因死亡率之间的U形关系，表明BRI对死亡结局具有预测价值。这些发现为将BRI用作非侵入性死亡风险筛查工具提供了有力支持。
