Huang Gongyu, She Xiangjun, Zhang Yun, Zhang Zongduan, Shen Lijun
National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Front Med (Lausanne). 2024 Jul 22;11:1344968. doi: 10.3389/fmed.2024.1344968. eCollection 2024.
To illustrate the characteristics of perforating scleral vessels in macular regions between mCNV eyes and contralateral eyes in unilateral mCNV patients.
This was a retrospective study that included patients with unilateral naive mCNV. The study aimed to identify and analyze the distribution of perforating scleral vessels (PSVs) in the macular region of mCNV eyes and contralateral eyes. The central macular choroidal thicknesses (mChT) were measured using optical coherence tomography angiography (OCTA). The grades of myopic atrophic maculopathy (MAM) and macular myopic diffuse chorioretinal atrophy (DCA) were evaluated within groups. The number of PSVs and mChT were compared between contralateral and mCNV eyes based on the grade of DCA. The ROC curves were utilized to explore the diagnostic indexes for mCNV.
A total of 102 eyes from 51 patients with unilateral mCNV were included. There was no significance in the severity of MAM or the grade of DCA between mCNV eyes and contralateral eyes ( = 0.074, = 0.054, respectively). The mean number of PSVs in mCNV eyes was fewer than the contralateral eyes [1.00 (1.00-2.00) vs. 2.00 (0.75-3.00), = 0.030]. The mChT in mCNV eyes was thinner than the contralateral eyes [36.00 (25.00-53.75) μm vs. 46.00 (31.00-75.25) μm, ]. The mean grade of DCA in mCNV eyes was higher than that in contralateral eyes [3.00 (3.00-3.00) vs. 3.00 (2.00-3.00), ]. When DCA involved the macular region, there were more PSVs in contralateral eyes than in mCNV eyes [1.50 (1.00-2.00) vs. 2.00 (1.00-3.00), ]. Similarly, when DCA involved the foveal region, there were more PSVs in contralateral eyes than in mCNV eyes [1.50 (1.00-2.00) vs. 3.00 (2.00-4.00), = 0.004]. The grade of DCA and mChT were valuable factors for predicting mCNV eyes ( = 0.6566, = 0.021; = 0.6304, = 0.029; respectively). When the extent of DCA exceeded the foveal region, the count of PSVs was a good diagnostic factor for predicting mCNV ( = 0.7430, = 0.003).
The mean amount of PSVs was significantly lower in the mCNV eyes compared to the contralateral eyes. When the extent of DCA exceeded the foveal region, the count of PSVs was a good diagnostic factor for predicting mCNV. Myopic eyes with a higher grade of DCA and a thinner mChT were more likely to develop mCNV.
阐述单侧黄斑中心凹下脉络膜新生血管（mCNV）患者患眼与对侧眼黄斑区巩膜穿通血管的特征。
这是一项回顾性研究，纳入单侧初发性mCNV患者。本研究旨在识别并分析mCNV患眼与对侧眼黄斑区巩膜穿通血管（PSV）的分布情况。使用光学相干断层扫描血管造影（OCTA）测量中心黄斑脉络膜厚度（mChT）。评估组内近视性萎缩性黄斑病变（MAM）和黄斑近视性弥漫性脉络膜视网膜萎缩（DCA）的分级。根据DCA分级比较对侧眼与mCNV患眼的PSV数量和mChT。利用ROC曲线探索mCNV的诊断指标。
共纳入51例单侧mCNV患者的102只眼。mCNV患眼与对侧眼的MAM严重程度或DCA分级无显著差异（分别为P = 0.074，P = 0.054）。mCNV患眼的PSV平均数量少于对侧眼[1.00（1.00 - 2.00）对2.00（0.75 - 3.00），P = 0.030]。mCNV患眼的mChT比对侧眼薄[36.00（25.00 - 53.75）μm对46.00（31.00 - 75.25）μm，P值未给出]。mCNV患眼的DCA平均分级高于对侧眼[3.00（3.00 - 3.00）对3.00（2.00 - 3.00），P值未给出]。当DCA累及黄斑区时，对侧眼的PSV比对mCNV患眼多[1.50（1.00 - 2.00）对2.00（1.00 - 3.00），P值未给出]。同样，当DCA累及黄斑中心凹区域时，对侧眼的PSV比对mCNV患眼多[1.50（1.00 - 2.00）对3.00（2.00 - 4.00），P = 0.004]。DCA分级和mChT是预测mCNV患眼的重要因素（分别为P = 0.6566，P = 0.021；P = 0.6304，P = 0.029）。当DCA范围超过黄斑中心凹区域时，PSV计数是预测mCNV的良好诊断因素（P = 0.7430，P = 0.003）。
与对侧眼相比，mCNV患眼的PSV平均数量显著减少。当DCA范围超过黄斑中心凹区域时，PSV计数是预测mCNV的良好诊断因素。DCA分级较高且mChT较薄的近视性眼更易发生mCNV。
