Alazmi Ahmed A, Brema Imad, Alzahrani Saad H, Almehthel Mohammed S
Obesity, Endocrine, and Metabolism Center, King Fahad Medical City, Riyadh, SAU.
Family Medicine and Endocrine Department, King Fahad Specialist Hospital, Dammam, SAU.
Cureus. 2024 Jul 6;16(7):e63947. doi: 10.7759/cureus.63947. eCollection 2024 Jul.
This study aimed to assess the correlation between glycated hemoglobin A1 (HbA1c), time in range (TIR), and glycemic management indicator (GMI) in patients with both type 1 diabetes (T1D) and type 2 diabetes (T2D) who were using a flash glucose monitoring (FGM) device (FreeStyle Libre; Abbott Diabetic Care, Witney, UK).
This was a retrospective study that looked at T1D and T2D FreeStyle Libre users' LibreView database in the period between January 2020 to June 2022. The study was conducted at the diabetes department at the King Fahad Medical City (KFMC) in Riyadh, Saudi Arabia, following Institutional Review Board (IRB) approval. Data were collected from the LibreView website, as well as from the electronic privacy information center (EPIC) hospital records.
Data were available for 327 patients, mean age of 33.08(±17.1) years old, and 55.7% were females. HbA1c had a statistically significant correlation with both TIR and GMI with coefficient of correlation (r) values of 0.78 (p<0.001) and 0.82 (p<0.001), respectively. A linear regression model between TIR and Hb1Ac was also developed and found to be statistically significant (p<0.001) with an acceptable R value (0.60).
Study findings revealed that the %TIR could be a reliable predictor of Hb1Ac. Thus, Freestyle Libre was able to determine Hb1Ac as close to the lab results as possible. Therefore, it is necessary to encourage diabetes patients to achieve at least 70% TIR in order to keep Hb1Ac within the desired range.
本研究旨在评估使用闪光葡萄糖监测（FGM）设备（FreeStyle Libre；雅培糖尿病护理公司，英国威特尼）的1型糖尿病（T1D）和2型糖尿病（T2D）患者糖化血红蛋白A1（HbA1c）、血糖达标时间（TIR）和血糖管理指标（GMI）之间的相关性。
这是一项回顾性研究，观察了2020年1月至2022年6月期间使用FreeStyle Libre的T1D和T2D患者的LibreView数据库。该研究在沙特阿拉伯利雅得法赫德国王医疗城（KFMC）糖尿病科进行，经机构审查委员会（IRB）批准。数据从LibreView网站以及电子隐私信息中心（EPIC）医院记录中收集。
共有327例患者的数据可用，平均年龄33.08（±17.1）岁，55.7%为女性。HbA1c与TIR和GMI均具有统计学显著相关性，相关系数（r）值分别为0.78（p<0.001）和0.82（p<0.001）。还建立了TIR与Hb1Ac之间的线性回归模型，发现具有统计学显著性（p<0.001），R值可接受（0.60）。
研究结果显示，TIR百分比可能是Hb1Ac的可靠预测指标。因此，FreeStyle Libre能够尽可能接近实验室结果地测定Hb1Ac。所以，有必要鼓励糖尿病患者使TIR至少达到70%，以便将HbA1c保持在理想范围内。
