Shaikh Jafar S, More Akash, Nair Nancy, Shrivastava Jarul, Pareek Charu
Clinical Embryology, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research, Nagpur, IND.
Clinical Embryology, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Jul 5;16(7):e63926. doi: 10.7759/cureus.63926. eCollection 2024 Jul.
Infertility affects millions globally, with advanced parental age posing a significant risk. This case report details a couple who experienced secondary infertility for 12 years. Following multiple unsuccessful attempts at assisted reproductive technology (ART), a personalized treatment regimen involving platelet-rich plasma (PRP) perfusion and laser-assisted hatching (LAH) resulted in a successful pregnancy. Diagnostic evaluations identified specific reproductive challenges, leading to tailored interventions. A positive pregnancy outcome was achieved after PRP treatment enhanced endometrial thickness and LAH facilitated embryo implantation. This case highlights the importance of individualized treatment strategies in infertility management and proves the potential efficacy of PRP and LAH in overcoming recurrent implantation failure. Further research is needed to explain the roles of PRP and LAH in improving pregnancy outcomes, especially in older parents and couples with a history of failed in vitro fertilization (IVF) treatments.
不孕症在全球影响着数百万人，父母年龄较大带来了重大风险。本病例报告详细介绍了一对经历了12年继发性不孕症的夫妇。在多次辅助生殖技术（ART）尝试失败后，一种包括富血小板血浆（PRP）灌注和激光辅助孵化（LAH）的个性化治疗方案导致了成功怀孕。诊断评估确定了具体的生殖挑战，从而进行了针对性干预。PRP治疗增加了子宫内膜厚度，LAH促进了胚胎着床，之后实现了积极的妊娠结局。本病例突出了个体化治疗策略在不孕症管理中的重要性，并证明了PRP和LAH在克服反复着床失败方面的潜在疗效。需要进一步研究来解释PRP和LAH在改善妊娠结局中的作用，特别是在年龄较大的父母以及有体外受精（IVF）治疗失败史的夫妇中。
