State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Curr Eye Res. 2024 Dec;49(12):1260-1268. doi: 10.1080/02713683.2024.2381864. Epub 2024 Aug 6.
The objective of this study was to observe the macular pigment optical density (MPOD) and the relationship between MPOD and retinal thickness in Chinese primary angle-closure glaucoma (PACG) patients by the one-wavelength reflectometry method.
This study was a prospective comparative observational study, including 39 eyes from 39 PACG patients (15 men and 24 women, mean age 61.89 ± 12.30) and 41 eyes from 41 controls (20 men and 21 women, mean age 63.24 ± 14.02). We measured the MPOD 7-degree area by the one-wavelength reflectometry method and analyzed both the max and mean optical density (OD). The central retinal thickness (CRT) and the total thickness of the macular ganglion cell layer (GCL), and inner plexiform layer (IPL)were measured by spectral-domain-optical coherence tomography (SD-OCT). Statistical methods such as Shapiro-Wilk test, Fisher's exact test, chi-square test, two independent samples test and Spearman's correlation coefficient were used to observe the differences in the MPOD between normal subjects and PACG patients and the correlation between the MPOD and retinal thickness.
The max optical density (Max OD) (PACG group: 0.302 ± 0.067d.u, control group: 0.372 ± 0.059d.u., < .001) and mean optical density (Mean OD) (PACG group: 0.124 ± 0.035d.u., control group: 0.141 ± 0.028d.u., < 0.05) were significantly reduced in PACG patients compared with control subjects. Significant decreases in GCL + IPL thickness (PACG group: 74.71 ± 39.56 μm, control group:113.61 ± 8.14 μm, < 0.001) and CRT (PACG group: 254.49 ± 41.47 μm, control group:329.10 ± 18.57 μm, < 0.001) were also observed in PACG eyes. There was no statistically significant correlation between the MPOD and GCL + IPL thickness ( = .639, = .828).
MPOD was significantly lower in Chinese PACG patients than in the control group, potentially due to thinning of the GCL + IPL thickness. This study provides insights for the pathophysiology, assessment of PACG and potential guidance for lifestyle modifications.
本研究旨在通过单波长反射计法观察中国人原发性闭角型青光眼（PACG）患者的黄斑色素光学密度（MPOD）和 MPOD 与视网膜厚度之间的关系。
这是一项前瞻性对比观察研究，纳入 39 只眼的 39 名 PACG 患者（男 15 例，女 24 例，平均年龄 61.89±12.30 岁）和 41 只眼的 41 名对照者（男 20 例，女 21 例，平均年龄 63.24±14.02 岁）。我们采用单波长反射计法测量 7 度区域的 MPOD，并分析最大和平均光密度（OD）。采用频域光学相干断层扫描（SD-OCT）测量中心视网膜厚度（CRT）和黄斑神经节细胞层（GCL）和内丛状层（IPL）的总厚度。采用 Shapiro-Wilk 检验、Fisher 确切检验、卡方检验、两独立样本检验和 Spearman 相关系数等统计方法观察正常人与 PACG 患者之间 MPOD 的差异以及 MPOD 与视网膜厚度之间的相关性。
PACG 患者的最大光密度（Max OD）（PACG 组：0.302±0.067d.u，对照组：0.372±0.059d.u， < .001）和平均光密度（Mean OD）（PACG 组：0.124±0.035d.u，对照组：0.141±0.028d.u， < 0.05）均明显低于对照组。PACG 眼的 GCL+IPL 厚度（PACG 组：74.71±39.56 μm，对照组：113.61±8.14 μm， < 0.001）和 CRT（PACG 组：254.49±41.47 μm，对照组：329.10±18.57 μm， < 0.001）也明显下降。MPOD 与 GCL+IPL 厚度之间无统计学显著相关性（ = .639， = .828）。
中国人 PACG 患者的 MPOD 明显低于对照组，可能与 GCL+IPL 厚度变薄有关。本研究为 PACG 的病理生理学、评估和潜在的生活方式改变提供了新的见解。
