五种豚鼠品系对梅毒螺旋体（Nichols株）感染易感性的差异

Wicher K, Wicher V, Gruhn R F

Genitourin Med. 1985 Feb;61(1):21-6. doi: 10.1136/sti.61.1.21.

Groups of 10 young male guinea pigs of inbred strains 2 and 13 and outbred strains Hartley A, Hartley B, and one deficient in the fourth component of complement (C4D) were infected intradermally with 80 X 10(6) Treponema pallidum (Nichols). The course of infection and production of antitreponemal antibody were examined. Strain C4D guinea pigs were the most susceptible to infection (100%); inbred strains 2 and 13 and outbred strain Hartley B showed 80-90% symptomatic infection; and the Hartley A strain was the least susceptible to infection (10%). Strain 13 animals responded with the highest antitreponemal antibody activity, and the Hartley A strain with the lowest. The results suggest that genetic factors or complement, or both, may influence the degree of susceptibility to infection with T pallidum in guinea pigs.

将10只近交系2和13以及远交系哈特利A、哈特利B的雄性幼龄豚鼠，和1只缺乏补体第四成分（C4D）的豚鼠组成一组，每组豚鼠皮内接种80×10⁶梅毒螺旋体（Nichols株）。对感染过程和抗梅毒螺旋体抗体的产生进行了检测。C4D品系豚鼠对感染最为敏感（100%）；近交系2和13以及远交系哈特利B表现出80 - 90%的有症状感染；而哈特利A品系对感染最不敏感（10%）。13品系动物产生的抗梅毒螺旋体抗体活性最高，哈特利A品系的抗体活性最低。结果表明，遗传因素或补体，或两者共同作用，可能会影响豚鼠对梅毒螺旋体感染的易感性程度。