Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Department of Nuclear Medicine, Daping Hospital, Army Medical University, Chongqing 400042, China.
Chem Commun (Camb). 2024 Aug 20;60(68):9082-9084. doi: 10.1039/d4cc03281k.
Naphthalocyanine-based agents exhibit huge potential in photodynamic therapy, yet their photodynamic performance is restricted by the penetration depth of the external laser. Herein, we employed F-FDG as an internal light source to excite silicon naphthalocyanine nanoparticles to simultaneously circumvent radiative transition and boost O generation for tumor suppression.
基于萘酞菁的试剂在光动力疗法中具有巨大的潜力，但它们的光动力性能受到外部激光穿透深度的限制。在此，我们采用 F-FDG 作为内部光源来激发硅萘酞菁纳米粒子，以同时避免辐射跃迁并促进 O 的生成，从而实现肿瘤抑制。
