Department of Chemistry, Zhejiang University, Hangzhou, 310028, China.
Chem Commun (Camb). 2018 Nov 20;54(93):13127-13130. doi: 10.1039/c8cc08445a.
Herein, we report a light-enhanced hypoxia-responsive nanoparticle for synergic treatment of solid tumors. The conversion of oxygen in the tumor exterior induced ROS and the continuous consumption of oxygen amplified the hypoxia conditions in the tumor, which enhanced the surface-to-core penetration of nanoparticles into the hypoxia central tissue.
在此，我们报告了一种光增强的缺氧响应性纳米颗粒，用于协同治疗实体瘤。肿瘤外部氧气的转化诱导了 ROS 的产生，并且氧气的持续消耗加剧了肿瘤内部的缺氧情况，从而增强了纳米颗粒从表面到核心穿透缺氧中心组织的能力。
