Cavalcante Israel Leal, Barros Caio César da Silva, Sousa Cruz Vitória Maria, Costa Mariana Bispo, da Silveira Santos Daniel Facó, de León-Garza Bernardo, Parra-Salazar Marco Antonio, Cruz-Tapia Roberto Onner, Rodriguez Brigitte, Manresa Carlos, Sánchez Gabriela, Villarroel-Dorrego Mariana, Turatti Eveline, Cavalcante Roberta Barroso, de Andrade Bruno Augusto Benevenuto
Department of Dentistry, University of Fortaleza (UNIFOR), Fortaleza, CE, Brazil.
Department of Oral Diagnosis and Pathology, Postgraduate Program in Dentistry, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Int J Surg Pathol. 2025 May;33(3):546-556. doi: 10.1177/10668969241266925. Epub 2024 Aug 6.
The primordial odontogenic tumor (POT) is a rare mixed odontogenic tumor composed of mesenchymal cells, columnar odontogenic epithelium, and fibromyxoid stroma affecting the posterior mandible of children and adolescents. Herein, we report 3 patients with POT and the clinicopathological features of POT previously reported in the literature. A 12-year-old, 19-year-old, and 4-year-old patient presented an asymptomatic swelling in the posterior maxilla and posterior mandible. Imaging exams revealed radiolucent lesions associated with unerupted teeth. The lesions were surgically removed, and the histopathological examination revealed spindle-to-ovoid mesenchymal cells in a fibromyxoid stroma surfaced by columnar odontogenic epithelial cells with reverse nuclear polarization. Deposition of mineralized tissue was observed. The final diagnosis was POT, and patients did not exhibit signs of recurrence. POT should be included in the differential diagnoses of intraosseous lesions in the posterior mandible in pediatric patients.
原始牙源性肿瘤（POT）是一种罕见的混合性牙源性肿瘤，由间充质细胞、柱状牙源性上皮和纤维黏液样基质组成，影响儿童和青少年的下颌后部。在此，我们报告3例POT患者以及文献中先前报道的POT的临床病理特征。一名12岁、一名19岁和一名4岁患者分别在上颌后部和下颌后部出现无症状肿胀。影像学检查显示与未萌出牙齿相关的透射性病变。病变经手术切除，组织病理学检查显示在纤维黏液样基质中有梭形至卵圆形间充质细胞，表面为柱状牙源性上皮细胞，核呈反向极化。观察到矿化组织沉积。最终诊断为POT，患者未表现出复发迹象。POT应纳入小儿患者下颌后部骨内病变的鉴别诊断中。
