锌通过上调Nrf2/HO-1/Nf-κB信号通路和雄激素受体基因减轻苯甲酸钠诱导的睾丸功能障碍。
Zinc abates sodium benzoate -induced testicular dysfunction via upregulation of Nrf2/ HO-1/ Nf-κB signaling and androgen receptor gene.
作者信息
Ajibare Ayodeji Johnson, Odetayo Adeyemi Fatai, Akintoye Olabode Oluwadare, Oladotun Ayotunde Jegede, Hamed Moses Agbomhere
机构信息
Department of Physiology, College of Medicine, Lead City University, Ibadan, Oyo-State, Nigeria.
Department of Physiology, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Ila Orangun, Nigeria.
出版信息
J Trace Elem Med Biol. 2024 Dec;86:127505. doi: 10.1016/j.jtemb.2024.127505. Epub 2024 Jul 26.
BACKGROUND
Sodium Benzoate (SB) is used in daily products such as drinks, juices, sauces, oils, ketchup, toothpaste, mouthwashes, cosmetics, dentifrices, and pharmaceutical products. However, SB has been implicated in gonadotoxicity even at a dosage within the safe limit. Zinc (Zn), on the other hand, has been shown to improve various fertility indices. Hence, this study was designed to explore the possible ameliorative effect of Zn on SB-induced testicular toxicity.
METHODS
Animals were randomly divided into control, SB, Zn, and SB+Zn. All treatment lasted for 28 days.
RESULTS
SB treatment caused a derangement in reproductive hormone levels, sperm function, and kinematics and a down-regulation of the Androgen receptor (ANDR). Also, a decrease in testicular levels of SOD, CAT, GSH, Nrf2, and HO- 1 activity and an increase in IL-1β, TNF-α, Nf-κB, and Caspase 3 were observed. These SB-induced distortions were ameliorated in SB-treated rats exposed to Zn.
CONCLUSION
Our study suggests that zinc abates SB-induced testicular toxicity by modulating Nrf2/HO-1/ Nf-κB signaling and ANDR upregulation.
背景
苯甲酸钠（SB）用于饮料、果汁、酱汁、油类、番茄酱、牙膏、漱口水、化妆品、洁齿剂和药品等日常产品中。然而，即使在安全剂量范围内，SB也与性腺毒性有关。另一方面，锌（Zn）已被证明可改善各种生育指标。因此，本研究旨在探讨锌对SB诱导的睾丸毒性可能的改善作用。
方法
将动物随机分为对照组、SB组、Zn组和SB + Zn组。所有处理持续28天。
结果
SB处理导致生殖激素水平、精子功能和运动学紊乱，以及雄激素受体（ANDR）下调。此外，观察到睾丸中SOD、CAT、GSH、Nrf2和HO-1活性水平降低，IL-1β、TNF-α、Nf-κB和Caspase 3增加。在暴露于锌的SB处理大鼠中，这些由SB诱导的畸变得到改善。
结论
我们的研究表明，锌通过调节Nrf2/HO-1/Nf-κB信号通路和上调ANDR来减轻SB诱导的睾丸毒性。
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