Department of Otorhinolaryngology, Children's Hospital of Nanjing Medical University, Jiangsu, PR China.
Department of Otorhinolaryngology, Children's Hospital of Nanjing Medical University, No. 72 of Guangzhou Road, Gulou District, Nanjing, 210008, Jiangsu, PR China.
Int J Pediatr Otorhinolaryngol. 2024 Aug;183:112053. doi: 10.1016/j.ijporl.2024.112053. Epub 2024 Aug 2.
This study aimed to investigate how central sleep apnea (CSA) impacts sleep patterns in children with obstructive sleep apnea (OSA).
Children undergoing polysomnography (PSG) were enrolled and sorted into two groups: those with OSA alone (Group A) and those with both OSA and CSA (CAI <1 nd: children with 10 % CSA or more and less than 50 %, Group B). Statistical analysis was conducted to compare sleep structure and clinical features between Group A and Group B.
Group B exhibited significantly higher respiratory events, apnea hypoventilation index, apnea index and oxygen desaturation index (ODI) compared to Group A (p < 0.05). Group B also showed higher total sleep time and arousal index than Group A (P < 0.05). The proportion of time spent in stage N3 was lower in Group B than in Group A (P < 0.05). Moreover, mean heart rate and minimum heart rate were higher in Group B compared to Group A (P < 0.05).Minimum oxygenation levels (including non-rapid eye movement (NREM) stages) were lowe in Group B than in Group A (P < 0.05). Additionally, the prevalence of positional obstructive sleep apnea (P-OSA) was greater in Group B than in Group A (P < 0.05).
In comparison to those with OSA alone, children with OSA and concurrent CSA exhibited distinct sleep patterns, including reduced N3uration, higher arousal index, longer respiratory events, higher ODI, and lower oxygen saturation, higher heart rate.
本研究旨在探讨中枢性睡眠呼吸暂停（CSA）如何影响阻塞性睡眠呼吸暂停（OSA）患儿的睡眠模式。
对接受多导睡眠图（PSG）检查的患儿进行入组，并分为两组：单纯 OSA 组（A 组）和 OSA 合并 CSA（CSA 指数＜1：CSA 占 10%以上且＜50%，CAI）患儿组（B 组）。对 A 组和 B 组的睡眠结构和临床特征进行比较。
B 组患儿的呼吸事件、呼吸暂停低通气指数、呼吸暂停指数和氧减指数（ODI）均显著高于 A 组（p＜0.05）。B 组患儿的总睡眠时间和觉醒指数也高于 A 组（P＜0.05）。B 组的 N3 期时间比例低于 A 组（p＜0.05）。与 A 组相比，B 组患儿的平均心率和最低心率更高（P＜0.05）。B 组患儿的最低氧饱和度（包括非快速眼动（NREM）期）较低（P＜0.05）。此外，B 组患儿的体位性阻塞性睡眠呼吸暂停（P-OSA）患病率高于 A 组（P＜0.05）。
与单纯 OSA 患儿相比，OSA 合并 CSA 的患儿具有明显不同的睡眠模式，包括 N3 期减少、觉醒指数增加、呼吸事件延长、ODI 增加、氧饱和度降低、心率升高。
